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Action of a serum against irradiated tumor tissue on the mitotic activity of Ehrlich's adenocarcinoma

  • Oncology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

Experiments proved that, compared with normal rabbit serum, sera against irradiated and nonirradiated tumors had a statistically significant depressive effect on the intensity of malignant cell division in subcutaneous Ehrlich's adenocarcinoma of mice (both in irradiated and nonirradiated animals).

All the sera mentioned had no significant effect on the mitotic activity of the corneal epithelium and crypts of the small intestine in experimental animals (both healthy and irradiated). The greatest percentages of undeveloped or weakly developed and necrotic tumors (74%) were observed in the group of irradiated mice and in those that were given the irradiated tumor supressing serum.

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Authors and Affiliations

  1. Laboratory of Noninfectious Immunology, Institute of Experimental Biology, AMN SSSR, Moscow

    S. V. Sukhorukikh

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  1. S. V. Sukhorukikh
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Sukhorukikh, S.V. Action of a serum against irradiated tumor tissue on the mitotic activity of Ehrlich's adenocarcinoma. Bull Exp Biol Med 57, 328–331 (1964). https://doi.org/10.1007/BF00781920

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  • DOI: https://doi.org/10.1007/BF00781920

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