Skip to main content
Log in

Disseminated infection ofPneumocystis carinii in a patient with the acquired immunodeficiency syndrome

  • Case Report
  • Published:
Virchows Archiv A Aims and scope Submit manuscript

Summary

This report describes the histopathology of a disseminatedPneumocystis carinii infecton in a 24-year-old Japanese male haemophiliac diagnosed as having the acquired immunodeficiency syndrome. He developed respiratory symptoms, andPneumocystis carinii pneumonia was confirmed by transbronchial lung biopsy. On the 70th day of hospitalization the patient died. Autopsy findings revealedPneumocystis carinii not only in the lungs but also in the stomach, jejunum, ileum, colon, mesoappendix, abdominal lymph nodes, diaphragm, and thyroid gland.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Anderson CD, Barrie HJ (1960) FatalPneumocystis pneumonia in an adult. Am J Clin Pathol 34:365–370

    Google Scholar 

  • Awen CF, Baltzan MA (1971) Systemic dissemination ofPneumocystis carinii pneumonia. Can Med Assoc J 104:809–812

    Google Scholar 

  • Barnett RN, Hull JG, Vortel V, Schwarz J (1969)Pneumocystis carinii in lymph nodes and spleen. Arch Pathol 88:175–180

    Google Scholar 

  • Brzosko WJ, Krawczyński K, Madaliński K, Nowoslawski A (1976) Immunopathologic aspects ofPneumocystis carinii pneumonia in infants as revealed by immunofluorescence and electron microscopy. In: Robbins JB, DeVita VT, Dutz W (eds) Symposium onPneumocystis carinii infection. National Cancer Institute, Bethesda, pp 163–168

    Google Scholar 

  • Burke BA, Good RA (1973)Pneumocystis carinii infection. Medicine 52:23–51

    Google Scholar 

  • Carter TR, Cooper PH, Petri WA Jr, Kim CK, Walzer PD, Guerrant RL (1988)Pneumocystis carinii infection of the small intestine in a patient with acquired immune deficiency syndrome. Am J Clin Pathol 89:679–683

    Google Scholar 

  • Centers For Disease Control (1985) Update: Acquired immunodeficiency syndrome - United States. MMWR 34:245–248

    Google Scholar 

  • Coulman CU, Greene I, Archibald RWR (1987) Cutaneous pneumocystosis. Ann Intern Med 106:396–398

    Google Scholar 

  • Frenkel JK (1976)Pneumocystis jiroveci n. sp. from man: Morphology, physiology, and immunology in relation to pathology. In: Robbins JB, DeVita VT, Dutz W (eds) Symposium onPneumocystis carinii infection. National Cancer Institute, Bethesda, pp 13–30

    Google Scholar 

  • Gagliardi AJ, Stover DE, Zaman MK (1987) EndobronchialPneumocystis carinii infection in a patient with the acquired immune deficiency syndrome. Chest 91:463–464

    Google Scholar 

  • Gallant JE, Enriquez RE, Cohen KL, Hammers LW (1988)Pneumocystis carinii thyroiditis. Am J Med 84:303–306

    Google Scholar 

  • Gherman CR, Ward RR, Bassis ML (1988)Pneumocystis carinii otitis media and mastoiditis as the initial manifestation of the acquired immunodeficiency syndrome. Am J Med 85:250–252

    Google Scholar 

  • Grimes MM, LaPook JD, Bar MH, Wasserman HS, Dwork A (1987) DisseminatedPneumocystis carinii infection in a patient with acquired immunodeficiency syndrome. Hum Pathol 18:307–308

    Google Scholar 

  • Henderson DW, Humeniuk V, Meadows R, Forbes IJ (1974)Pneumocystis carinii pneumonia with vascular and lymph nodal involvement. Pathology 6:235–241

    Google Scholar 

  • Heyman MR, Rasmussen P (1987)Pneumocystis carinii involvement of the bone marrow in acquired immunodeficiency syndrome. Am J Clin Pathol 87:780–783

    Google Scholar 

  • Hughes WT, Price RA, Kim H-K, Coburn TP, Grigsby D, Feldman S (1973)Pneumocystis carinii pneumonitis in children with malignancies. J Pediatr 82:404–415

    Google Scholar 

  • Jarnum S, Rasmussen EF, Ohlsen AS, Sørensen AWS (1968) GeneralizedPneumocystis carinii infection with severe idiopathic hypoproteinemia. Ann Intern Med 68:138–145

    Google Scholar 

  • Kwok S, O'Donnell JJ, Wood IS (1982) Retinal cotton-wool spots in a patient withPneumocystis carinii infection. N Engl J Med 307:184–185

    Google Scholar 

  • LeGolvan DP, Heidelberger KP (1973) Disseminated granulomatousPneumocystis carinii pneumonia. Arch Pathol 95:344–348

    Google Scholar 

  • Macher AM, Bardenstein DS, Zimmerman LE, Steigman CK, Pastore L, Poretz DM, Eron LJ (1987)Pneumocystis carinii choroiditis in a male homosexual with AIDS and disseminated pulmonary and extrapulmonaryP. carinii infection. N Engl J Med 316:1902

    Google Scholar 

  • Pavlica F (1962) Erste Beobachtung von angeborener Pneumozystenpneumonie bei einem reifen, ausgetragenen totgeborenen Kind. Zbl Allg Path 103:236–241

    Google Scholar 

  • Pilon VA, Echols RM, Celo JS, Elmendorf SL (1987) DisseminatedPneumocystis carinii infection in AIDS. N Engl J Med 316:1410–1411

    Google Scholar 

  • Price RA, Hughes WT (1974) Histopathology ofPneumocystis carinii infestation and infection in malignant disease in childhood. Hum Pathol 5:737–752

    Google Scholar 

  • Rahimi SA (1974) DisseminatedPneumocystis carinii in thymic alymphoplasia. Arch Pathol 97:162–165

    Google Scholar 

  • Rossi J-F, Dubois A, Bengler C, Arich C, Gervais C, Délage A, Janbon C (1985)Pneumocystis carinii in bone marrow. Ann Intern Med 102:868

    Google Scholar 

  • Schinella R, Breda SD, Hammerschlag PE (1987) Otic infection due toPneumocystis carinii in an apparently healthy man with antibody to the human immunodeficiency virus. Ann Intern Med 106:399–400

    Google Scholar 

  • Steigman CK, Pastore L, Park CH, Fox CH, DeVinatea ML, Connor DH, Macher AM (1987) AIDS case for diagnosis series, 1987 military medicine. Militarty Medicine 152:M1-M8

    Google Scholar 

  • Unger PD, Rosenblum M, Krown SE (1988) DisseminatedPneumocystis carinii infection in a patient with acquired immunodeficiency syndrome. Hum Pathol 19:113–116

    Google Scholar 

  • Zandanell E (1954) Pneumozystisbefund außerhalb der Lunge bel interstitieller plasmazellulärer Pneumonie der Säuglinge und Frühgeburten. Zbl Allg Pathol 92:74–80

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

Contribution No. 627 from the Department of Medical Zoology, Kyoto Prefectural University of Medicine

Rights and permissions

Reprints and permissions

About this article

Cite this article

Matsuda, S., Urata, Y., Shiota, T. et al. Disseminated infection ofPneumocystis carinii in a patient with the acquired immunodeficiency syndrome. Vichows Archiv A Pathol Anat 414, 523–527 (1989). https://doi.org/10.1007/BF00781710

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00781710

Key words

Navigation