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Immunocytochemical demonstration of IGF-II-like immunoreactivity in human paraganglioma of the craniocervical region

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Summary

Insulin-like-growth factor (IGF)-II-like immunoreactivity was examined in two carotid bodies and six extra-adrenal paragangliomas with use of monoclonal antibody against rat IGF-II, which crossreacts with human IGF-II. Chief cells but not sustentacular cells of the carotid body were positive at about 10% in one case and less than 1% in another case.

Among four carotid body tumours, a possible vagal body tumour and one glomus jugulare tumour, all but the glomus jugulare tumour exhibited positive tumour cells irrespective of histological variations. The frequency of positive cells ranged from 20 to 60%. IGF-II like immunoreactivity, therefore, might be widely distributed in human extra-adrenal paraganglionic tissues and tumours, although its biological role in these cells remains to be elucidated.

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Authors and Affiliations

  1. Department of Pathology, Fukushima Medical College, Japan

    Toshimitsu Suzuki

  2. Department of Pathology, Niigata University School of Medicine, Japan

    Mitsuya Iwafuchi

  3. Department of Neuropathology, Brain Research Institute, Niigata University, Japan

    Hitoshi Takahashi & Fusahiro Ikuta

  4. Department of Biochemistry, Kanazawa Medical University, Japan

    Katsuzo Nishikawa & Hideyuki Tanaka

  5. Laboratory of Bioorganic Chemistry, University of Shizuoka, School of Pharmaceutical Science, Japan

    Noboru Yanaihara

Authors
  1. Toshimitsu Suzuki
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  2. Mitsuya Iwafuchi
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  3. Hitoshi Takahashi
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  4. Fusahiro Ikuta
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  5. Katsuzo Nishikawa
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  6. Hideyuki Tanaka
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  7. Noboru Yanaihara
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Additional information

This work is supported in part by a Grant-in-Aids from the Ministry of Health and Welfare (T.S. and NY), and from the Ministry of Education, Science and Culture (M.I., N.Y., and F.I.).

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Suzuki, T., Iwafuchi, M., Takahashi, H. et al. Immunocytochemical demonstration of IGF-II-like immunoreactivity in human paraganglioma of the craniocervical region. Vichows Archiv A Pathol Anat 414, 515–521 (1989). https://doi.org/10.1007/BF00781709

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  • DOI: https://doi.org/10.1007/BF00781709

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