Summary
The effect of subcutaneous application of 9,10-dimethyl-1,2-benzanthracene on the process of tumor formation was studied. Different dose of this preparation were tested, i.c., 1.0 mg in crystalline form, 1.0 mg in rat fat, 1.0, 0.5 and 0.3 mg in peach oil. Various methods of introduction of the stimulant did not affect the regular change of the stages of this process (inflammation, sclerosis, hyperplasia, formation of the focus of malignant growth). However, the method of application and the dose influenced the degree of reactivity during separate stages. The differing character of inflammatory reactions (stage 1) influenced the development of sclerotic changes (stage II), which in turn had an effect on the degree of development of hyperplastic changes during the IIIrd stage. In certain cases more rapid carcinogenesis could be connected with pronounced hyperplastic changes, in others — with appearance of a small number of tumors which formed later. The above data allow us to draw a conclusion that the protective-adaptive reactions which are observed in the focus in the focus of tumor formation may determine one or another outcome of the whole process.
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Literature Cited
I.A. Avdeeva, Proceedings of a Scientific Conference on the Problem: The Nervous System in the Milignant Process and Allied Questions In Russian. (Kiev. 1955). pp. 61–65.
Iu.M. Vasil'ev, Voprosy Onkol. 1, 1, 5–16 (1955).
Z.V. Gol'dberg and L.M. Shabad, Malignant Tumors In Russian. (Moscow, 1948), pp. 23–38.
A.M. Diad'kova, Problems of Oncology. In Russian. (Moscow, 1952), 5, pp. 141–50.
S.I. Lebedinskaia and A.A. Solov'ev. Proceedings of a Scientific Conference on the Problem: The Nervous System in the Malignant Process, and Allied Questions In Russian (Kiev, 1955), pp. 9–11.
V.M. Lumpova, New Findings on the Histogenesis of Experimentally Induced Sarcomas, Author's Abstract of Candidate's Dissertation In Russian. (Sverdlovsk, 1953).
E.Ia. Smoilovskaia, Problems of Oncology In Russian (Moscow, 1951), 3, pp. 247–254.
A.A. Solov'ev and S.I. Lebedinskaia, Scientific Proceedings of the 10th Session of the General Council of the Acad. Med. Sci. USSR (March 19–24, 1956) In Russian (Moscow, 1956), pp. 20–24.
M.O. Raushenbakh, Biull Ekspil. Biol. i Med. 2, 443–446 (1950).
M.O. Raushenbakh, Arkh. Patol. 3, 47–58 (1949).
L.M. Shabad, Arkh. Biol. Nauk SSSR 39, 1–3, 753–767 (1935).
L.M. Shabad, Biull. Eksptl. Biol. I Med. 18, 6, 66–69 (1944).
F. Dickens and F. Weil-Malherbe, Cancer Research 2, 560–566 (1942).
C. Oberling, P. Guerin, M. Guerin and C. Sannie, Compt. rend. Soc. de biol. 130, 17–19 (1939).
C. Oberling, M. Guerin and P. Guerin, Bull. Assoc. franc. pour l'etude de cancer 28, 2, 198–213 (1939).
P.R. Peacock and S. Beck, British J. exper. Path. 19, 315–319 (1938).
P.R. Peacock, S. Beck and W. Anderson, Brit. J. cancer 3, 296 (1949).
J.J. Morton and H.B. Mider, Proc. Soc. exper. biol. a. med. 41, 357–360 (1939).
P. Rondoni, Ztschr. Krebsforschung 47, 59–83 (1937).
M.B. Shimkin and H.B. Anderwont, Pub. health reports 55, 537–545 (1940).
J.W. Orr, J. path. a. bact. 49, 157–70 (1939).
L.A. Strait, M.K. Hirenoff and K.B. De Orne, Cancer res. 8, 231–240 (1948).
J.M. Twort and C.C. Twort, Am. J. cancer 35, 80–85 (1939).
H.P. Rush, Physiol rev. 24, 177–204 (1944).
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Submitted by Active Member Acad. Med. Sci. USSR V.N. Chernigovskii
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Klimenko, E.D. The effect of the mode of administration and the dose of a carcinogenic agent on the development of morphological changes in the focus of tumor formation. Bull Exp Biol Med 45, 514–519 (1958). https://doi.org/10.1007/BF00781267
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DOI: https://doi.org/10.1007/BF00781267