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Alterations in gastric function produced by the action of the antigen of the dysentery bacillus upon the intestinal mucous membrane

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

Pronounced and prolonged disfunction of the stomach results from the introduction of the dysentery bacillus antigen into isolated (by Pavlov's method) portions of the small and large intestine. This is due to the fact that the antigen not only stimulates the nervous apparatus of the intestine, but is also absorbed. Irrigation of isolated portions of the intestine by the Thiry-Vella method, which prevents absorption of the antigen (this was proved by experiments with labeled antigen) is also associated with disturbed function of the stomach, which, however, differs qualitatively. It was demonstrated on animals deprived of parasympathetic innervation of the stomach that the function is disturbed when the antigen is introduced into the isolated protions of intestes. This shows that the sympathetic innervation of the stomach and certain humoral factors take part in the influence of the intestine on the gastric function. Therefore, both the neuroflex mechanism and the humoral factors participate in interoceptive transmission from the intestine to the stomach.

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Authors and Affiliations

  1. Laboratory of Pathological Physiology of the Institute of Infectious Diseases, Acad. Med. Sci. USSR, Kiev

    E. A. Brodskaia

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  1. E. A. Brodskaia
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Brodskaia, E.A. Alterations in gastric function produced by the action of the antigen of the dysentery bacillus upon the intestinal mucous membrane. Bull Exp Biol Med 45, 445–449 (1958). https://doi.org/10.1007/BF00781253

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  • DOI: https://doi.org/10.1007/BF00781253

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