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The effect of the dose of tumor tissue antigens on the production of specific antibodies

  • Oncology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

The antigen dosage of the Ehrlich's ascitic tumor tissue employed, in immunization of rabbits has a considerable effect on the titer of specific antibodies. However, the antitumor antibody production depends directly on the dosate of the antigens only when administered up to a certain moment following which an increase of the dose does not promote the rise of the specific antibody

After cessation of immunization the antibody production has an undulating character. At one time it is the antitumor antibodies that prevail in the serum, while at the other, the antisplenic antibodies, By a constant serological control of dynamics of the antibody production it is possible to obtain a serum with a considerable prevalence of the antitumor antibodies.

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Literature Cited

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Authors and Affiliations

  1. Laboratory of Noninfectious Immunology of the Institute of Experimental Biology of the AMN SSSR, Moscow

    P. P. Filatov

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  1. P. P. Filatov
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Filatov, P.P. The effect of the dose of tumor tissue antigens on the production of specific antibodies. Bull Exp Biol Med 47, 750–754 (1959). https://doi.org/10.1007/BF00781236

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  • DOI: https://doi.org/10.1007/BF00781236

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