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The prolonged heterogeneous implantation of mouse tumors in rats

Communication III. The use of the agglutination reaction to study the antigenic properties of the cells of Ehrlich's ascitic carcinoma of mice after prolonged implantation in rats

  • Oncology
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Bulletin of Experimental Biology and Medicine Aims and scope

Summary

The antigenic content of Ehrlich's mouse carcinoma transplanted for more than a year on young rats was studied with the aid of cancer cell agglutination reaction (in M. M. Kapichnikov's modification). Rat species-specific antigens appear on the surface of cancer cells begining from the first generation of rats, evidently, at the expense of the rat protein adsorption. In addition to this, after 50 generations, certain mouse species-specific antigens disappear from the surface of cancer cells. Identical results are obtained in complement fixation reaction. The loss of mouse antigens is accompanied by a simultaneous decline in the growth of the tumor heterotransplants on mice.

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Literature Cited

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Authors and Affiliations

  1. Division of Immunobiology of the Institute of Experimental Biology of the AMN SSSR, Moscow

    I. I. Podopielov

Authors
  1. I. I. Podopielov
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Podopielov, I.I. The prolonged heterogeneous implantation of mouse tumors in rats. Bull Exp Biol Med 47, 745–749 (1959). https://doi.org/10.1007/BF00781235

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  • DOI: https://doi.org/10.1007/BF00781235

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