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Preservation of the poliomyelitis virus when dried by the sublimation method (preliminary communication)

  • L. S. Lozovskaya
Microbiology and Immunity
  • 14 Downloads

Summary

The possibility of drying of the poliomyelitis virus is of great significance for obtaining not only the standard antigen for the diagnostic investigations, but also the stable live vaccine against poliomyelitis from nonpathogenic strains, one of which (type 11P-712[5]) was employed in the present work. The survival of the poliomyelitis virus during the process of drying of the culture fluid media was studied. Positive results were obtained. When drying the culture in the presence of egg yolk and saccharose the titer of the dry preparations was on the average lower than in the initial material by 1 point of ogarythim, viz., the viability reached 10%. A definite relationship between the survival of the virus and the concentration of the protective medium was revealed.

Keywords

Public Health Saccharose Positive Result Initial Material Culture Fluid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Literature Cited

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    S. Gard, Poliomyelitis, pp. 183–200, Moscow, 1957 [Russian translation].Google Scholar
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    M. I. Sokolov, Zhur Mikrobiol. Épidemiol i Imminobiol., No. 10, 57–62 (1953).Google Scholar
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    M. Pollard, Proc. Soc. Exper. Biol. and Med., 1951, v. 78, pp. 388–392.Google Scholar
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    A. B. Sabin, J.A.M.A., 1956, v. 162, pp. 1589–1596.Google Scholar
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    M. Theiler and S. Gard, J. Exper. Med., 1940, v. 72, pp. 49–67.Google Scholar

Copyright information

© Consultants Bureau Inc. 1960

Authors and Affiliations

  • L. S. Lozovskaya
    • 1
  1. 1.Moscow Research Institute for Preparations against PoliomyelitisMoscowUSSR

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