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The effect of 2-methylnaphthoquinone on the various elements of the neuromuscular apparatus in cold-blooded animals

  • Pharmacology
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Bulletin of Experimental Biology and Medicine Aims and scope

Summary

The authors studied the effect of 2-methylnapthoquinone on the frog's skeletal muscle, the nerve stem and the proprioceptors. A reduction of contractions and development of muscle contracture resulting from the effect of this preparation was noted. The action currents become monophasic in character and their wave length increases. Their transformation occurs with stimuli of lower frequencies. The lability of the nerve stem is also reduced. The excitability of the proprioceptors, as well as the frequency of the proprioceptive impulsation is decreased. “Prolongation” of the excitation waves and reduction in stability of the elements under investigation is, evidently, connected with disturbance of the acetylcholine synthesis and deficiency in this chemical agent.

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Authors and Affiliations

  1. Department of Physiology of the Kazan Medical Institute, Kazan, USSR

    L. N. Zefirov & G. I. Poletaev

Authors
  1. L. N. Zefirov
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  2. G. I. Poletaev
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Zefirov, L.N., Poletaev, G.I. The effect of 2-methylnaphthoquinone on the various elements of the neuromuscular apparatus in cold-blooded animals. Bull Exp Biol Med 47, 721–724 (1959). https://doi.org/10.1007/BF00781229

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  • DOI: https://doi.org/10.1007/BF00781229

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