Summary
Changes in the EEG caused by the action of aminazine (phenothiazine derivative) on puppies, ages from 1 to 18 days, differ from those typical for older puppies and adult dogs. Not only slow “slumber” potentials are absent in the puppies under 18 days of age, but there is also a certain increase of the frequency-amplitude characteristics. This fact confirms the view accepted in Professor I. A. Árshavskii's laboratory on the absence of the functional maturation of the corresponding nuclei in the ascending portion of the reticular system in young animals. The neuroplegic properties of aminazine are manifested in puppies only by the 18th–20th day of life.
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Rozanova, V.D. An electroencephalographic analysis of the distinctive features of the action of aminazine (chlorpromazine) on dogs of different ages. Bull Exp Biol Med 47, 715–720 (1959). https://doi.org/10.1007/BF00781228
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DOI: https://doi.org/10.1007/BF00781228