Changes in the reflex variations of arterial pressure and respiration during induction of hypothermia by various methods

  • N. V. Klykov
Pathological Physiology and General Pathology


Experiments were performed on 24 cats. The authors studied variations of the arterial blood pressure and respiration obtained by extracorporeal cooling of the blood pumped from the superior vena cava into the femoral vein and by direct overcooling of the head through the skin surface or by cooling the blood in the carotid artery.

Hypothermia induced by any method would cause a gradual increase of the threshold of faradic excitability of the vasomotor center, decrease in the fluctuation range of the arterial blood pressure, and also intensify the inhibition of the respiratory center in stimulatiog the vagus nerve. This points to the reduction of the reflex excitability and development of the parabiotic inhibition in these centers. However, their excitability was still preserved at the body and brain temperature of about 20°C. Warming of an overcooled body restored the excitability of the centers.


Public Health Blood Pressure Carotid Artery Arterial Pressure Gradual Increase 
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Copyright information

© Consultants Bureau Inc. 1960

Authors and Affiliations

  • N. V. Klykov
    • 1
  1. 1.Department of Normal Physiology of the Kuban Medical InstituteKrasnodar

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