The influence of the mode of administration of adsorbed toxoids on the rate of development of immunity to tetanus and gas gangrene

  • L. A. Pevnitskii
Microbiology and Immunity


It was demonstrated in experiments on white rats that the rate of immunity development in primary immunization with sorbed tetanus and gangrenous toxoids is the same, irrespective of whether these toxoids be injected in a single dose or in 9 fractions at the same site and with an interval of 3 hours. These data differ from the results obtained with liquid tetanus toxoids, the fractional administration of which causes an earlier appearance of immunity than a single injection. The efficacy of the sorbed toxoids appeared to be the same in subcutaneous and intramuscular injection. Several experiments in which fractional administration of sorbed tetanus toxoid appeared to be more effective than a single one are discussed from the standpoint of modern conceptions on the mechanism of antigen action.


Public Health Single Dose Tetanus Intramuscular Injection Single Injection 
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Copyright information

© Consultants Bureau, Inc. 1959

Authors and Affiliations

  • L. A. Pevnitskii
    • 1
  1. 1.Laboratory of Infectious Pathology of the Division of General Pathology of the Institute of Normal and Pathological Physiology of the AMN SSSRMoscow

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