Summary
The analgesic effect of the phenothiazine series derivatives (Mepazine, Aminazine and Propazine) and of analgesics (morphine, Promedole and Phenadone) was studied by the method of electric pain stimulation.
The presence of analgesia potentiation was established. Combinations of phenothiazine derivatives with Promedole proved most effective. Bilateral potentiation during concurrent use of phenothiazine derivatives and analgesics is also manifest in the appearance of hypnotic effect.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
Yu. I. Vikhiyaev, Farmakol. i Toksikol.21, 1, 28 (1958).
Yu. I. Vikhiyaev and D. A. Kharkevich, Farmakol. i Toksikol.21, 1, 44 (1958).
M. D. Mashkovskii, S. S. Liberman, and A. I. Polezhaeva, Farmakol. i Toksikol.18, 1, 14 (1955).
S. Courvoisier, et al., Arch. Int. Pharmacodyn.92, 305 (1953).
A. B. Dobkin, et al., Anaesthesia10, 328 (1955).
R. W. Houde and S. L. Wallenstein, Fed. Proc.14, 353 (1955).
H. Kopera and A. K. Armitage, Brit. J. Pharmacol.9, 392 (1954).
O. Nieschulz, K. Popendiker, and I. Hoffmann, Arzneimittel-Forsch.5, 680 (1955).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Barkov, N.K. The influence of phenothiazine derivatives on the action of analgesics. Bull Exp Biol Med 51, 185–188 (1961). https://doi.org/10.1007/BF00779652
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00779652