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The antigenic properties of the red cells in leukemia

Communication I. Differentiation of the antigenic properties of normal and leukemic red cells by the specific delay of precipitation test in agar using antiserum against leukemic splenic tissue

  • Oncology
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Bulletin of Experimental Biology and Medicine Aims and scope

Summary

By their antigenic properties the erythrocytes of leukemic patients differ from those of healthy donors of the same blood group (by the ABO and Rh systems). These differences are revealed in the reaction of specific inhibition of precipitation in agar with the antiserum obtained by immunization of rabbits with the leukemic splenic tissue.

By inhibiting precipitation through introduction of surplus erythrocytes of healthy donors into agar, the antiserum would not reveal their full range (incomplete inhibition) or, in reacting with them, would not form any lines of precipitation at all. It was against this background that the lines of precipitation formed in reaction of the antiserum with the erythrocytic antigens of leukemic patients were especially pronounced.

In 262 tests out of 293 (in 89% of all cases) the erythrocytes of patients suffering from various forms of leukemia could be differentiated from those of healthy donors by their antigenic properties.

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Authors and Affiliations

  1. Division of Immunology and Malignant Tumors of the N. F. Gamaleya Institute of Epidemiology and Microbiology of the AMN SSSR, Moscow

    V. A. Parnes

Authors
  1. V. A. Parnes
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Additional information

The subject matter of this article formed part of a lecture given at the 36th Plenum of the Central Order of Lenin Institute of Blood Transfusion on June 3. 1957.

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Parnes, V.A. The antigenic properties of the red cells in leukemia. Bull Exp Biol Med 47, 495–498 (1959). https://doi.org/10.1007/BF00779634

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  • DOI: https://doi.org/10.1007/BF00779634

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