Summary
It was possible to reveal the dissociation between the reflex and the “automatic” actions of the vibra on septique toxin in decorticated animals. In these conditions the white rats perished when the toxin was injected into the brain or blood. In repeated intramuscular injection of the toxin in fractional doses the process of summation of the pathogenic stimuli was absent and the animals did not die from intoxication.
The pathogenetic experimental therapy of gas gangrene was conducted with consideration of this regularity when coupled with the barbamyl sleep, which decreases the reactivity of the animals to the pathogenic stimulation. The specific serum gave a better effect, than the separate use of these components.
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Sobieva, Z.I. The mechanism of development of gas gangrene. Bull Exp Biol Med 47, 429–432 (1959). https://doi.org/10.1007/BF00779620
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DOI: https://doi.org/10.1007/BF00779620