Summary
The author studied the effect of various doses of cortisone on the aspetic (agar-agar) and infectious (B. pneumoniae) inflammation by the method of determination of the degree of the leucocytic activity of the friable connective tissue. The quantitative regularities governing the depression rate of the infiltration by different doses of cortisone were found to be same in both types of inflammation. It gradually rises with the increase of the cortisone dose from 1.3 to 12.0 mg/kg. By increasing the cortisone dose to 20 mg/kg the infiltration becomes still greater. The apparent absence of any effect of large cortisone doses on the inflammation is due (in infectious cases) to a considerable increase in the number of microbes at the site of their introduction and points to the decline in the tissue factor activity of the body resistance.
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Literature Cited
N. A. Shmelev, Problemy Tuberk., 3, 20–28 (1957).
T. F. Dougherty and G. L. Schneebeli, Ann. New York Acad. Sc., 61, 328–348 (1955).
L. W. Kinsell and J. P. Jahn, Ann. New York Acad. Sc., 61, 397–407 (1955).
Opsahl et al., Yale J. Biol. a. Med., 23, 399–406 (1951).
J. Seifter, et al., Proc. Soc. Exp. Biol. a. Med., 75, 337–342 (1950).
J. E. Smadel et al., Ann. Intern. Med., 34, 1–9 (1951).
D. M. Spain and N. Molomut, Am. J. Clin. Path., 22, 944–947 (1952).
C. A. Winter and L. Flataker, Proc. Soc. Exp. Biol. a Med., 79, 312–314 (1952).
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Solov'ev, V.N. The paradoxical action of large doses of cortisone in infective and aseptic inflammation. Bull Exp Biol Med 47, 424–428 (1959). https://doi.org/10.1007/BF00779619
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DOI: https://doi.org/10.1007/BF00779619