The influence of inflammation on the regeneration of muscle in experiments with minced muscle tissue

Summary

Experiments (2 series) were conducted on white rats. The significance of the characterof inflammatory process for the restoration of the muscles was demonstrated by the method of autotransplantation of minced muscular tissue. Only isolated fragments of material transplanted in place of removed muscles of the posterior extremity underwent narcosis and resolutions the greater part of the minced muscular tissue appeared to be viable and underwent radical reconstruction, bringing about the development of myoblasts, muscle tubes, and differentiated cross-striated muscle fibers supplied with nerve elements. A typical muscular organ was formed as a result of restorative process. Necrosis of minced muscular fibers was intensified in the presence of purulent inflammation; their progressive development and the resolution of necrotic particles became sharply retarded and the productive development and the resolution of necrotic particles became sharply retarded and the productive development of connective tissue, resulting in the formation of connective tissue reproduction at the site of the transplant, was stimulated