Summary
The mechanism of increased thromboplastin activity of the blood was studied on 100 patients operated on in connection with fibromyoma of the uterus and in 25 experiments with acute blood loss in dogs. The thromboplastin activity increased during the postoperative period by one and a half times, antithromboplastin activity by two and a half times. These changes occurred as soon as 2.5 hours after the operation, being most pronounced on the third day. The number of blood platelets increased insignificantly and only on the eighth postoperative day. Acute blood loss is associated with increased thromboplastin activity, reduction of antithromboplastin activity and a drop of the platelet count. The rise of the blood thromboplastin activity after the operations and blood losses are associated with reduced blood antithromboplastin activity. Increased blood thromboplastin activity, leading to accelerated blood coagulation, should be regarded as one of the manifestaions of “stress” reaction.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
Bazaron, S. Ts., Sov. med., 3, 36 (1954).
Baluda, V. P., Pat. fiziol. i éksper. ter., 6, 41 (1957).
Baluda, V. P., Pat. fiziol. i éksper. ter., 5, 79 (1959).
Markosyan, A. A., Abstracts of Proceedings of the 9th Congress of the All-Union Association of Physiologists, Biochemists and Pharmacologists [in Russian] (Moscow-Minsk, 1959) Vol. 1, p. 292.
Chernaya, V. V., Abstracts of Proceedings of the Scientific Session of Kuban Medical School [in Russian] (Krasnodar, 1959) p. 87.
Briggs, R., Douglas, A. S. and MacFerlane, R. G., J. Physiol.122, 538 (1953).
Briggs, R., Douglas, A. S. and MacFerland, R. G., J. Physiol.122, 554 (1953).
Brinkhous, K. M. and Graham, J. B., Blood9, 254 (1954).
Brinkhous, K. M., Sang25, 738 (1954).
Goller, F. A., Job, V. W., Conn, J. W. et al. Ann. Surg.132, 374 (1950).
Cormsten, J., Koagulationsproblemer ved acut coronartrombose med experimentelt supplement (Copenhagen, 1957).
Gouttas et. al., Acta haemat.12, 203 (Basel, 1954).
Graham, J. B., Langdell, R. D. and Brinkhous, K. M., in the book: The Coagulation of Blood, p. 117 (New York, 1955).
Jaques, L. B., et al., in the book: The Coagulation of Blood, p. 26 (New York, 1955).
Johnson, S. A., Am. J. Clin. Path.23, 875 (1953).
MacFerlane, R. G., Physiol. Rev.36, 479 (1956).
Nicola, P., Rev. Hemat.9, 536 (1954).
Poller, L., Angiology5, 21 (1954).
Quick, A. J., Am. J. med. Sci.214, 272 (1947).
Shanderge, J. N., Sarelis, A. and Regan, E. E., J. Lab. clin. Med.54, 501 (1959).
Tocantins, L. M., Carroll, R. T. and Holburn, R. H., Blood6, 720 (1951).
Tocantins, L. M., Blood9, 281 (1954).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Baluda, V.P., Chernaya, V.V. The problem of the thromboplastin activity of the blood. Bull Exp Biol Med 51, 424–427 (1961). https://doi.org/10.1007/BF00779526
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00779526