Pharmaceutical Chemistry Journal

, Volume 12, Issue 10, pp 1299–1304 | Cite as

Influence of methylcobalamin on the antineoplastic activity of methotrexate

  • F. G. Arsenyan
  • N. V. Myasishcheva
  • Z. P. Sof'ina
  • M. O. Raushenbakh
  • I. P. Rudakova
  • E. G. Chauser
  • A. M. Yurkevich
Search for New Drugs


Organic Chemistry Methotrexate Antineoplastic Activity Methylcobalamin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature cited

  1. 1.
    N. V. Myasishcheva, Characteristics of Metabolism of B-12 Compounds (Cobalamins) in Leukemia Doctoral Dissertation [in Russian], Moscow (1972).Google Scholar
  2. 2.
    H. Sauer and L. Jaenicke, Blut,28, 321–327 (1974).Google Scholar
  3. 3.
    O. D. Golenko and N. V. Myasishcheva, Probl. Gematol., No. 5, 24–28 (1971).Google Scholar
  4. 4.
    O. D. Golenko, Influence of Cobalamins (B-12 compounds) on the Morphofunctional State of Tissues of the Hemopoietic System. Candidate's Dissertation [in Russian], Moscow (1975).Google Scholar
  5. 5.
    N. V. Myasishcheva, O. D. Golenko, and M. O. Raushenbakh, in: The Role of Endogenous Factors in the Development of Leukemias [in Russian], Moscow (1974), pp. 151–169.Google Scholar
  6. 6.
    N. V. Myasishcheva, O. D. Golenko, L. E. Kuznetsova, et al., Vopr. Med. Khim., No. 5, 622–628 (1977).Google Scholar
  7. 7.
    H. Ashe, B. R. Clark, F. Chu, et al., Biochem. Biophys. Res. Commun.,57, 417–425 (1974).Google Scholar
  8. 8.
    Yu. V. Vares and N. V. Myasishcheva, Vopr. Med. Khim., No. 5, 681–684 (1977).Google Scholar
  9. 9.
    R. A. Gams, E. M. Ryel, and L. M. Meyer, Proc. Soc. Exp. Biol. (N. Y.),149, 384–388 (1975).Google Scholar
  10. 10.
    R. Peirce, A. Tsukasa, and B. A. Cooper, Biochim. Biophys. Acta,381, 348–358 (1975).Google Scholar
  11. 11.
    J. H. Mangum, K. Byron, B. K. Murray, et al., Biochemistry (Wash.),8, 3496–3499 (1969).Google Scholar
  12. 12.
    G. T. Burke, J. H. Mangum, and J. D. Brodie, Biochemistry (Wash.),16, 3079–3085 (1971).Google Scholar
  13. 13.
    F. M. Huennekens, P. M. DiGrolomo, K. Fujii, et al., Adv. Enzyme Regul.,14, 187–205 (1975).Google Scholar
  14. 14.
    Z. P. Sof'ina, N. V. Myasishcheva, F. G. Arsenyan, et al., Vesti, AMH SSSR, No. 5, 36–39 (1978).Google Scholar
  15. 15.
    O. D. Golenko, N. V. Myasishcheva, M. O. Raushenbakh, et al., Vopr. Med. Khim., No. 5, 549–554 (1974).Google Scholar
  16. 16.
    Z. P. Sof'ina, Vopr. Onkol., No. 4, 82–96 (1976).Google Scholar
  17. 17.
    W. Friedrich and J. P. Nordmeyer, Z. Naturforsch,24b, 588–596 (1969).Google Scholar
  18. 18.
    G. J. Atwell and B. F. Cain, J. Med. Chem.,16, 673–678 (1973).Google Scholar
  19. 19.
    E. G. Chauser, I. P. Rudakova, and A. M. Yurkevich, Zh. Obshch. Khim.,46, 360–365 (1976).Google Scholar
  20. 20.
    O. S. Frankfurt, Cell Mechanisms of Tumor Chemotherapy [in Russian], Moscow (1976).Google Scholar
  21. 21.
    R. A. Alimov, Influence of Certain Stimulators of Hemopoiesis on the Biological Activity of Alkylating Antineoplastic Compounds. Candidate's Dissertation [in Russian], Tashkent (1964).Google Scholar
  22. 22.
    Z. P. Bulkina and P. R. Polyak, Vopr. Onkol., No. 4, 70–75 (1968).Google Scholar
  23. 23.
    G. F. Dyadyusha and Z. P. Bulkina, in: Materials of the Sixth Republican Conference of Oncologists of the Lithuanian SSR [in Russian], Vil'nyus (1964), p. 194.Google Scholar
  24. 24.
    J. C. Linnel, E. V. Quadros, D. M. Matthews, et al., Cancer Res.,37, 2975–2978 (1977).Google Scholar
  25. 25.
    L A. Kudryavtsev, O. D. Golenko, and N. V. Myasishcheva, Probl. Gematol., No. 3, 26–29 (1978).Google Scholar
  26. 26.
    G. Tisman and V. Herbert, Blood,41, 465–469 (1973).Google Scholar
  27. 27.
    D. Goldman, Cancer Chemother. Rep.,6, Pt. 3, 63–72 (1975).Google Scholar

Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • F. G. Arsenyan
    • 1
    • 2
  • N. V. Myasishcheva
    • 1
    • 2
  • Z. P. Sof'ina
    • 1
    • 2
  • M. O. Raushenbakh
    • 1
    • 2
  • I. P. Rudakova
    • 1
    • 2
  • E. G. Chauser
    • 1
    • 2
  • A. M. Yurkevich
    • 1
    • 2
  1. 1.Oncological Scientific Center of the Academy of Medical Sciences of the USSRUSSR
  2. 2.Scientific-Industrial Vitamin CombineMoscow

Personalised recommendations