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Bleomycin induces cataract formation in newborn rats in association with modifications of crystallin synthesis

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Abstract

The antitumor antibiotic Bleomycin induces the formation of cataract when injected into newborn rats but not when injected into rats after 12 days or older. The development of these lesions is strictly associated with progressive biochemical modifications of the crystallins as demonstrated by electrophoresis on one and two-dimensional gels. When the lenses of the rats are observed histologically, the first modifications appear between 7 and 13 days after the injection of the drug concomitatly with the first biochemical modifications. Lateron the fiber cells start to degenerate and there is a gradual destruction of the whole center of the lens.

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Authors and Affiliations

  1. Institut d'Immuno-Biologie, (U.20 INSERM et La 143 CNRS), Hopital Broussais, 96, rue Didot, 75674, Paris Cedex 14, France

    Jean-Claude Weill & Gerald Leca

  2. Biochimie de la Différenciation, Université Paris VII, 2, Place Jussieu, 75221, Paris Cedex 05, France

    Alain Vincent

  3. UER d'Ophthalmologie, Hôtel-Dieu, Place du Parvis Notre-Dame, 75004, Paris, France

    Jacques Cotinat

Authors
  1. Jean-Claude Weill
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  2. Gerald Leca
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  3. Alain Vincent
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  4. Jacques Cotinat
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Weill, JC., Leca, G., Vincent, A. et al. Bleomycin induces cataract formation in newborn rats in association with modifications of crystallin synthesis. Mol Biol Rep 4, 207–210 (1979). https://doi.org/10.1007/BF00777555

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  • DOI: https://doi.org/10.1007/BF00777555

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