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A model for the involvement of the small nucleolar RNA (U3) in processing eukaryotic ribosomal RNA

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Abstract

The nucleotide sequence of chick pre-rRNA between 5.8S and 28S rRNAs is 85% G+C and has the potential to form many different secondary structures. A model is presented in which a small nucleolar RNA, U3, and its associated proteins act as an RNA isomerase to position the pre-rRNA for processing. Cleavage could be performed either by a nuclease present in the U3RNP or by a ribonuclease directed to the proper form of the pre-rRNA.

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Authors and Affiliations

  1. Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, 20205, Bethesda, MD, USA

    R. J. Crouch, S. Kanaya & P. L. Earl

Authors
  1. R. J. Crouch
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  2. S. Kanaya
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  3. P. L. Earl
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Crouch, R.J., Kanaya, S. & Earl, P.L. A model for the involvement of the small nucleolar RNA (U3) in processing eukaryotic ribosomal RNA. Mol Biol Rep 9, 75–78 (1983). https://doi.org/10.1007/BF00777476

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