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Molecular Biology Reports

, Volume 10, Issue 2, pp 65–68 | Cite as

Permeability to inhibitors of protein synthesis in virus infected cells

  • C. Fernández-Puentes
Article

Abstract

Infection of HeLa cells with different viruses induces permeabilization of the cell membrane to protein toxins such as α-sarcin. This phenomenon occurs with HeLa, KB, BHK-21 and L929 cells and EMC, SFV, VSV and Polio virus and is dependent on the ability of the virus to infect the cells. Inhibitors of endocytosis and lysosomotropic agents do not affect this process. Cells become sealed to the toxin approximately four hours after the infection. Sulfhydryl reagents impair cellular permeabilization to α-sarcin.

Keywords

Cell Membrane Protein Synthesis HeLa Cell Infected Cell Sulfhydryl 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Dr W. Junk Publishers 1984

Authors and Affiliations

  • C. Fernández-Puentes
    • 1
  1. 1.Departamento de Microbiología, Centro de Biología MolecularUniversidad Autónoma de MadridMadridSpain

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