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Molecular Biology Reports

, Volume 6, Issue 1, pp 27–29 | Cite as

Inhibition of exogenous mRNA translation in a cell-free system by chromatin peptides from calf thymus

  • Gian L. Gianfranceschi
  • Marian Hillar
  • Jan Przyjemski
  • Domenico Amici
  • Luigi Guglielmi
Article

Abstract

Low molecular weight chromatin peptides isolated from calf thymus by affinity chromatography on DNA-cellulose inhibit significantly translation of exogenous isolated mRNA in a reticulocyte cell-free system. Translation with endogenous mRNA present in the system is not inhibited by low peptide concentrations. The data obtained combined with the previous findings suggest that chromatin peptides control gene expression at two levels: transcription and translation.

Keywords

Peptide Gene Expression Molecular Weight Affinity Chromatography Peptide Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Dr. W. Junk B.V. Publishers, The Hague 1980

Authors and Affiliations

  • Gian L. Gianfranceschi
    • 1
  • Marian Hillar
    • 1
  • Jan Przyjemski
    • 1
  • Domenico Amici
    • 2
  • Luigi Guglielmi
    • 2
  1. 1.Department of BiologyTexas Southern UniversityHoustonUSA
  2. 2.Institute of General PhysiologyUniversity of CamerinoCamerino (Mc)Italy

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