Mechanism for inactivation of polyene antibiotics
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The process of complete and partial oxidation of nystatin by potassium permanganate in an acid medium is studied. With complete oxidation of the antibiotic, the main reaction product is succinic acid, and with partial, a mixture of succinic, oxalic, malonic, and lactic acids, identified by the methods of paper and gas-liquid chromatography. These same acids are formed on inactivation of nystatin during storage. On inactivation of nystatin under “moist chamber” conditions, acetone and acetaldehyde are included in the mixture of low-molecular dehydration products.
KeywordsAcetaldehyde Potassium Acetone Organic Chemistry Lactic Acid
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