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Glycoconjugate Journal

, Volume 8, Issue 6, pp 450–455 | Cite as

Solid phase synthesis of the fibronectin glycopeptide V(Galβ3GalNAcα)THPGY, its β analogue, and the corresponding unglycosylated peptide

  • B. Lüning
  • T. Norberg
  • C. Rivera-Baeza
  • J. Tejbrant
Papers

Abstract

The fibronectin fragment VTHPGY and the corresponding glycopeptides V(Galβ3GalNAcα)THPGY and V(Galβ3GalNAcβ)THPGY were synthesized by the FMOC/solid phase approach. FMOC derivatives of threonine, carrying O-linked, peracetylated Galβ3GalNAc chains were used for introduction (HOBt-mediated coupling) of the disaccharide moieties.

Keywords

glycopeptide synthesis fibronectin 

Abbreviations

FMOC

9-fluorenylmethyloxycarbonyl

DMTST

dimethyl(thiomethyl)sulfonium triflate

DMF

dimethylformamide

BOC

butoxycarbonal

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Copyright information

© Chapman & Hall 1991

Authors and Affiliations

  • B. Lüning
    • 1
  • T. Norberg
    • 2
  • C. Rivera-Baeza
    • 1
  • J. Tejbrant
    • 1
  1. 1.Department of Organic ChemistryStockholm UniversityStockholmSweden
  2. 2.Organic Synthesis Department, BioCarb Technology ABLundSweden

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