Mycopathologia

, Volume 100, Issue 1, pp 49–53 | Cite as

Genotoxic activity of some mycotoxins using the SOS chromotest

  • Y. Auffray
  • P. Boutibonnes
Article

Abstract

The genotoxic activity of 11 mycotoxins was investigated inEscherichia coli K 12. The induction of the SOS functionsfi A whose level of expression is monitored by means of asfi A:: lac Z operon fusion was assayed by measuring theβ-galactosidase activity in the PQ 37 strain. Most of these fungal metabolites did not induce SOS response in this bacterial test. Only aflatoxicol, a reduced metabolite of aflatoxin B1 was well detected as an SOS inducer if metabolic activation was performed. Patulin, penicillic acid and viomellein are only weak inducing agents. The other fungal compounds tested failed to demonstrate a positive SOS inducing activity. Relationship between SOS chromotest, mutagenicity toSalmonella typhimurium andin vivo carcinogenicity was discussed.

Key words

genotoxicity SOS chromotest mycotoxins 

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Copyright information

© Martinus Nijhoff/Dr W. Junk Publishers 1987

Authors and Affiliations

  • Y. Auffray
    • 1
  • P. Boutibonnes
    • 1
  1. 1.Laboratoire de Génétique Microbienne, Unité de Toxicologie GénétiqueIRBA, Université de CaenCaen CedexFrance

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