Journal of Bioenergetics and Biomembranes

, Volume 24, Issue 1, pp 91–98 | Cite as

High-conductance pathways in mitochondrial membranes

  • Oscar Moran
  • M. Catia Sorgato


The outer and inner membranes of mitochondria have recently been studied with the patch clamp technique. What has emerged is still an ill-defined picture for either membrane, primarily for the wide range of conductances found. Interestingly, however, a few conductances (in the range of 10–80 pS) seem to be ubiquitously distributed. Parallel studiesin situ and in reconstituted systems have allowed the assignment to distinct membrane locations of some conductances, whose physiological role is, however, not yet elucidated.

Key words

Channels intracellular membrane channels mitochondrial channels patch clamp 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Antonenko, Y. N., Kinnally, K. W., Perini, S., and Tedeschi, H. (1991).FEBS Lett. 285, 89–93.Google Scholar
  2. Amchenkova, A. A., Bakeeva, L. E., Chentsov, Y. S., Skulachev, V. P., and Zorov, D. B. (1988).J. Cell Biol. 107, 481–495.Google Scholar
  3. Benz, R. (1990).Experientia 46, 131–137.Google Scholar
  4. Benz, R., Kottke, M., and Brdiczka, D. (1990).Biochim. Biophys. Acta 1022, 311–318.Google Scholar
  5. Colombini, M. (1979).Nature (London)279, 643–645.Google Scholar
  6. Colombini, M. (1986). InIon Channel Reconstitution (Miller, C., ed.), Plenum Press, New York, pp. 533–551.Google Scholar
  7. Criado, M., and Keller, B. U. (1987).FEBS Lett. 224, 172–176.Google Scholar
  8. Costa, G., Kinnally, K. W., and Diwan, J. J. (1991).Biochem. Biophys. Res. Commun. 175, 305–310.Google Scholar
  9. De Pinto, V., Ludwig, O., Krause, J., Benz, R., and Palmieri, F. (1987).Biochim. Biophys. Acta 894, 109–119.Google Scholar
  10. Dihanich, M., Schmid, A., Oppliger, W., and Benz, R. (1989).Eur. J. Biochem. 181, 703–708.Google Scholar
  11. Freitag, H., Neupert, W., and Benz, R. (1982).Eur. J. Biochem. 123, 629–636.Google Scholar
  12. Galante, Y. M., Wong, S., and Hatefi, Y. (1981).Arch. Biochem. Biophys. 211, 643–651.Google Scholar
  13. Hackenbrock, C. R. (1968).Proc. Natl. Acad. Sci. USA 61, 598–605.Google Scholar
  14. Hamill, O. P., Marty, A., Neher, E., Sakmann, B., and Sigworth, F. J. (1981).Pflügers Arch. Eur. J. Physiol. 391, 85–100.Google Scholar
  15. Kinnally, K. W., Tedeschi, H., and Mannella, C. A. (1987).FEBS Lett. 226, 83–87.Google Scholar
  16. Kinnally, K. W., Campo, M. L., and Tedeschi, H. (1989).J. Bioenerg. Biomembr. 21, 497–506.Google Scholar
  17. Kinnally, K. W., Zorov, D., Antonenko, Y. N., and Perini, S. (1991).Biochem. Biophys. Res. Commun. 176, 1183–1188.Google Scholar
  18. Kottke, M., Adam, V., Riesinger, I., Bremm, G., Bosch, W., Brdiczka, D., Sandri, G., and Panfili, E. (1988).Biochim. Biophys. Acta 935, 87–102.Google Scholar
  19. LaNoue, K. F., and Schoolworth, A. C. (1979).Annu. Rev. Biochem. 48, 871–992.Google Scholar
  20. Moran, O., Sandri, G., Panfili, E., Stühmer, W., and Sorgato, M. C. (1990).J. Biol. Chem. 265, 908–913.Google Scholar
  21. Moran, O., Sciancalepore, M., Sandri, G., Panfili, E., Bassi, R., Ballarin, C., and Sorgato, M. C. (1991).Eur. Biophys. J., in press.Google Scholar
  22. Petronilli, V., Szabó, I., and Zoratti, M. (1989).FEBS Lett. 259, 137–143.Google Scholar
  23. Pfanner, N., and Neupert, W. (1990).Annu. Rev. Biochem. 59, 331–353.Google Scholar
  24. Sandri, G., Siagri, M., and Panfili, E. (1988).Cell Calcium 9, 159–165.Google Scholar
  25. Schein, S. J., Colombini, M., and Finkelstein, A. (1976).J. Membr. Biol. 30, 99–120.Google Scholar
  26. Schleyer, M., and Neupert, W. (1985).Cell 43, 339–350.Google Scholar
  27. Skulachev, V. P. (1988).Membrane Bioenergetics, Springer-Verlag, Berlin.Google Scholar
  28. Sorgato, M. C., Lippe, G., Seren, S., and Ferguson, S. J. (1985).FEBS Lett. 181, 323–327.Google Scholar
  29. Sorgato, M. C., Keller, B. U., and Stühmer, W. (1987).Nature (London)330, 498–500.Google Scholar
  30. Sorgato, M. C., Moran, O., De Pinto, V., Keller, B. U., and Stühmer, W. (1989).J. Bioener. Biomembr. 21, 485–496.Google Scholar
  31. Spray, D. C., Saez, J. C., Brosius, D., Bennet, M. V. L., and Hertzberg, E. L. (1986).Proc. Natl. Acad. Sci. USA 83, 5494–5497.Google Scholar
  32. Szabó, I., and Zoratti, M. (1991).J. Biol. Chem. 266, 3376–3379.Google Scholar
  33. Tandler, B., and Hoppel, C. L. (1973).J. Biol. Chem. 56, 266–272.Google Scholar
  34. Tedeschi, H., Mannella, C. A., and Bowman, C. L. (1987).J. Membr. Biol. 97, 21–29.Google Scholar
  35. Thieffry, M., Chich, J-F., Goldshmidt, D., and Henry, J-P. (1988).EMBO J. 7, 1449–1454.Google Scholar
  36. Wunder, U. R., and Colombini, M. (1991).J. Membr. Biol. 123, 83–91.Google Scholar
  37. Zoratti, M., Petronilli, V., and Azzone, G. F. (1986).Biochim. Biophys. Acta 851, 123–135.Google Scholar
  38. Zorov, D. B., Kinnally, K. W., Perini, S., and Tedeschi, H. (1991).Biophys. J. 59, 216a.Google Scholar

Copyright information

© Plenum Publishing Corporation 1992

Authors and Affiliations

  • Oscar Moran
    • 1
  • M. Catia Sorgato
    • 2
  1. 1.Laboratorio di NeurofisiologiaScuola Internazionale Superiore di Studi AvanzatiTriesteItaly
  2. 2.Dipartimento di Chimica BiologicaUniversitá di Padova e Centro CNR per lo Studio della Fisiologia MitocondrialePadovaItaly

Personalised recommendations