Pharmaceutical Chemistry Journal

, Volume 1, Issue 1, pp 42–44 | Cite as

Indolylalkylthioureas and their tuberculostatic activity

  • G. N. Pershin
  • T. N. Zykova
  • N. N. Suvorov
  • V. S. Fedorova
  • V. N. Buyanov
Brief Communications
  • 13 Downloads

Abstract

The reaction of 5-methoxytryptamine with silicon tetraisothiocyanate has given N-[β-(5-methoxy-3-indolyl)ethyl]thiourea, and N,N'-di[β-(5-methoxy-3-indolyl)ethyl]thiourea has been synthesized by heating 2 moles of 5-methoxytryptamine hydrochloride with 1 mole of ammonium thiocyanate. The reaction of tryptamines with aryl isothiocyanates has given the unsymmetrical disubstituted N-β-3-indolylethyl-N'-phenylthioureas. All the thioureas have been converted by the action of methyl iodide into S-methylisothiouronium hydriodides. By the reaction of indolylalkyl bromides with thiourea, S-indolylalkylisothiouronium salts have been synthesized. The compounds obtained have been subjected to chemotherapeutic study.

Keywords

Methyl Silicon Ammonium Ethyl Bromide 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature cited

  1. 1.
    M. N. Shchukina, Med. Prom. SSSR, No. 4, 18 (1961); N. B. Galstukhova and M. N. Shchukina, Med. Prom. SSSR, No. 8, 15 (1960).Google Scholar
  2. 2.
    D. Doherty and W. Burnett, Proc. Soc. Exptl. Biol. Med.,89, 312 (1955).Google Scholar
  3. 4.
    N. N. Suvorov, N. P. Sorokina, and G. N. Tsvetkova, Zh. Obshch. Khim.,34, 1595 (1964).Google Scholar
  4. 5.
    T. Vitali and F. Mossini, Boll. Sci. Fac. Chim. Ind. Bologna,17, 84 (1959); Chem. Abstr.54, 19644 (1960); F. Lingens and K. Weiler, Lieb. Ann.,662, 139 (1963); Toshio Hoshino and Kenya Shimodaira, Bull. Chem. Soc. Japan,11, 221 (1936); Chem. Abstr.,30, 5982 (1936).Google Scholar

Copyright information

© Consultants Bureau 1968

Authors and Affiliations

  • G. N. Pershin
    • 1
  • T. N. Zykova
    • 1
  • N. N. Suvorov
    • 1
  • V. S. Fedorova
    • 1
  • V. N. Buyanov
    • 1
  1. 1.S. Ordzhonikidze All-Union Pharmaceutical Chemistry Research InstituteMoscow

Personalised recommendations