Indolylalkylthioureas and their tuberculostatic activity
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The reaction of 5-methoxytryptamine with silicon tetraisothiocyanate has given N-[β-(5-methoxy-3-indolyl)ethyl]thiourea, and N,N'-di[β-(5-methoxy-3-indolyl)ethyl]thiourea has been synthesized by heating 2 moles of 5-methoxytryptamine hydrochloride with 1 mole of ammonium thiocyanate. The reaction of tryptamines with aryl isothiocyanates has given the unsymmetrical disubstituted N-β-3-indolylethyl-N'-phenylthioureas. All the thioureas have been converted by the action of methyl iodide into S-methylisothiouronium hydriodides. By the reaction of indolylalkyl bromides with thiourea, S-indolylalkylisothiouronium salts have been synthesized. The compounds obtained have been subjected to chemotherapeutic study.
KeywordsMethyl Silicon Ammonium Ethyl Bromide
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