Abstract
Studies of esterification of thiamine and its phosphoric esters by various phosphorylating agents have shown that the reaction proceeds in a variety of ways with the formation of a mixture of phosphates of different composition. In some cases thiamine is more difficult to esterify than its phosphoric esters. Cocarboxylase and thiamine triphosphate are formed from thiamine monophosphate; with an increase of temperature,the reaction shifts toward polyphosphate formation. During phosphorylation of cocarboxylase and thiamine triphosphate, besides an esteriflcation reaction, partial rupture of the pyro- and triphosphate bonds takes place, with the formation of thiamine monophosphate.
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V. M. Berezovskii, V. I. Koltunova, E. A. Shlimovich, et al., Zh. Obshch. Khim.32, 3890 (1962).
V. M. Berezovskii, V. I. Koltunova, E. D. Pekel', et al., Zh. Obshch. Khim.33, 49 (1963).
L. Flexser and W. Farkas, U.S. Patent No. 2610178, Chem. Abstr.47, 8781 (1953).
Ito Hirofumi, Hasumi Tsuneo, and Tanabe Kejiti, Japanese Patent No. 10326, (1960); Ref. Zh. Khimiya, No. 6L118 (1962).
Walter Hansgünter, East German Patent No. 22437, (1961); Ref. Zh. Khimiya, No. 14L139 (1962).
H. G. Khorana and J. P. Vizsolvi, J. Am. Chem. Soc.,85, 4660 (1959).
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Translated from Khimiko-Farmatsevticheskii Zhurnal, No. 2, pp. 10–14, February, 1967.
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Koltunova, V.I., Berezovskii, V.M. Nucleotides, coenzymes, phosphoric esters. Pharm Chem J 1, 68–71 (1967). https://doi.org/10.1007/BF00768081
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DOI: https://doi.org/10.1007/BF00768081