Skip to main content
SpringerLink
Log in

Pharmacokinetic modeling of the elimination of drugs by the liver. II. Influence of the localization and activity of metabolizing enzymes and the rate of blood flow in the liver on the clearance of drugs (review)

  • Molecular Biological Problems in the Creation of Drugs and Study of the Mechanism of their Action
  • Published:
Pharmaceutical Chemistry Journal Aims and scope

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. P. V. Gulak, A. M. Dudchenko, V. V. Zaitsev, et al., The Hepatocyte: Functional-Metabolic Properties [in Russian], Moscow (1985).

  2. L. Bass, S. Keiding, K. Winkler, and N. Tygstrup, J. Theor. Biol.,61, 393–409 (1976).

    Google Scholar 

  3. L. Bass, J. Theor. Biol.,86, 365–376 (1980).

    Google Scholar 

  4. L. Bass, Am. J. Physiol.,244, G583-G589 (1983).

    Google Scholar 

  5. L. Bass, Circulation,72, Suppl. IV, 47–52 (1985).

    Google Scholar 

  6. R. E. Billings, R. E. McMahon, J. Ashmore, and S. R. Wagle, Biochem. Pharmacol.,25, 516–526 (1977).

    Google Scholar 

  7. A. Blom, A. H. J. Scaf, and D. K. F. Meijer, Biochem. Pharmacol.,31, 1553–1565 (1982).

    Google Scholar 

  8. J. M. Collins, D. A. Blake, and P. G. Egner, Drug Metab. Dispos.,6, 251–257 (1978).

    Google Scholar 

  9. J. G. Conway, F. C. Kauffman, S. Ji, and R. G. Thurman, Mol. Pharmacol.,22, 509–516 (1982).

    Google Scholar 

  10. J. G. Conway, F. C. Kauffman, T. Tsukuda, and R. G. Thurman, Mol. Pharmacol.,33, 111–119 (1988).

    Google Scholar 

  11. J. R. Dawson, J. G. Weitering, G. J. Mulder, et al., J. Pharmacol. Exp. Ther.,234, 691–697 (1985).

    Google Scholar 

  12. M. Gascon-Barre, N. Benbrahim, and C. Tremblay, Can. J. Physiol. Pharmacol.,67, 1015–1022 (1989).

    Google Scholar 

  13. J. R. Gillette, K. S. Pang, Clin. Pharmacol. Ther.,22, 623–629 (1977).

    Google Scholar 

  14. C. A. Goresky, Am. J. Physiol.,207, 13–26 (1964).

    Google Scholar 

  15. C. A. Goresky, G. G. Bach, and B. E. Nadeau, J. Clin. Invest.,52, 991–1009 (1973).

    Google Scholar 

  16. C. A. Goresky, Fed. Proc.,41, 3033–3039 (1982).

    Google Scholar 

  17. C. A. Goresky, G. G. Bach, and C. P. Rose, Am. J. Physiol.,244, G215-G230 (1983).

    Google Scholar 

  18. G. M. M. Groothius, M. J. Hardonk, K. P. T. Keulemans, et. al., Am. J. Physiol.,243, G455-G462 (1982).

    Google Scholar 

  19. G. M. M. Groothius, K. P. T. Keulemans, M. J. Hardonk, et al., Biochem. Pharmacol.,32, 3069–3078 (1983).

    Google Scholar 

  20. C. M. M. Groothius, M. J. Hardonk, D. K. F. Meijer, Trends Pharmacol. Sci.,6, 322–327 (1985).

    Google Scholar 

  21. J. J. Gumucio and D. L. Miller, Gastroenterology,80, 393–403 (1981).

    Google Scholar 

  22. J. J. Gumucio, D. L. Miller, M. D. Krauss, and C. C. Zanolli, Gastroenterology,80, 639–646 (1981).

    Google Scholar 

  23. D. L. Gumucio, J. J. Gumucio, J. A. P. Wilsin, et al., Am. J. Physiol.,246, G86-G95 (1984).

    Google Scholar 

  24. R. James, P. Desmond, A. Kupfer, et al., J. Pharmacol. Exp. Ther.,217, 127–132 (1981).

    Google Scholar 

  25. A. L. Jones, G. T. Hradek, R. H. Renston, et. al., Am. J. Physiol.,238, G233-G237 (1980).

    Google Scholar 

  26. K. Jungermann and N. Katz, Hepatology,2, 385–395 (1982).

    Google Scholar 

  27. T. Kashiwagi, K. O. Lindros, S. Ji, et al., J. Pharmacol. Exp. Ther.,224, 538–542 (1983).

    Google Scholar 

  28. S. Keiding, S. Johansen, K. Winkler, et al., Am. J. Physiol.,230, 1302–1313 (1976).

    Google Scholar 

  29. S. Keiding and E. Chiarantini, J. Pharmacol. Exp. Ther.,205, 465–470 (1978).

    Google Scholar 

  30. S. Keiding, S. Johansen, I. Midtbll et al., Am. j. Physiol.,237, E316-E324 (1979).

    Google Scholar 

  31. S. Keiding and E. Steiness, J. Pharmacol. Exp. Ther.,230, 474–477 (1984).

    Google Scholar 

  32. H. Koster, I. Halsema, E. Scholtens, et al., Biochem. Pharmacol.,31, 3023–3028 (1982).

    Google Scholar 

  33. H. Koster and G. J. Mulder, Drug Metab. Dispos.,10, 330–335 (1982).

    Google Scholar 

  34. E. D. Massey and W. H. Butler, Chem. Biol. Interact.,24, 329–334 (1979).

    Google Scholar 

  35. D. L. Miller, C. S. Zanolli, and J. J. Gumucio, Gastroenterology,76, 965–969 (1979).

    Google Scholar 

  36. S. Miyauchi, Y. Sugiyama, Y. Sawada, et al., J. Pharmacokinet. Biopharm.,15, 25–38 (1987).

    Google Scholar 

  37. D. J. Morgan, D. B. Jones, and R. A. Smallwood, Hepatology,5, 1231–1235 (1985).

    Google Scholar 

  38. M. E. Morris and K. S. Pang, J. Pharmacokinet. Biopharm.,15, 473–496 (1987).

    Google Scholar 

  39. M. E. Morris, V. Yuen, B. K. Tang, and K. S. Pang, J. Pharmacol. Exp. Ther.,245, 614–624 (1988).

    Google Scholar 

  40. M. E. Morris, V. Yuen, and K. S. Pang, J. Pharmacokinet. Biopharm.,16, 633–656 (1988).

    Google Scholar 

  41. A. S. Nies, D. G. Shand, and G. R. Wilkinson, Clin. Pharmacokinet.,1, 135–155 (1976).

    Google Scholar 

  42. K. S. Pang and M. Rowland, J. Pharmacokinet. Biopharm.,5, 655–680 (1977).

    Google Scholar 

  43. K. S. Pang and M. Rowland, J. Pharmacokinet. Biopharm.,5, 681–699 (1977).

    Google Scholar 

  44. K. S. Pang and J. R. Gillette, Drug Metab. Dispos.,6, 567–576 (1978).

    Google Scholar 

  45. K. S. Pang and J. R. Gillette, J. Pharmacol. Exp. Ther.,207, 178–194 (1978).

    Google Scholar 

  46. K. S. Pang and J. R. Gillette, J. Pharmacokinet. Biopharm.,6, 335–367 (1978).

    Google Scholar 

  47. K. S. Pang, M. Rowland, and T. M. Tozer, Drug Metab. Dispos.,6, 197–200 (1978).

    Google Scholar 

  48. K. S. Pang and J. R. Gillette, J. Pharmacokinet. Biopharm.,7, 275–290 (1979).

    Google Scholar 

  49. K. S. Pang, K. Strobl, and J. R. Gillette, Drug Metab. Dispos.,7, 366–372 (1979).

    Google Scholar 

  50. K. S. Pang, Trends Pharmacol. Sci.,1, 247–251 (1980).

    Google Scholar 

  51. K. S. Pang and J. R. Gillette, Drug Metab. Dispos.,8, 39–43 (1980).

    Google Scholar 

  52. K. S. Pang, J. Pharmacokinet. Biopharm.,9, 477–487 (1981).

    Google Scholar 

  53. K. S. Pang and J. A. Terrell, J. Pharmacol. Exp. Ther.,216, 339–346 (1981).

    Google Scholar 

  54. K. S. Pang, H. Koster, I. C. M. Halsema, et al., J. Pharmacol. Exp. Ther.,219, 134–140 (1981).

    Google Scholar 

  55. K. S. Pang, L. Waller, M. G. Horning, and K. K. Chan, J. Pharmacol. Exp. Ther.,222, 14–21 (1982).

    Google Scholar 

  56. K. S. Pang, Drug Metab. Rev.,14, 61–76 (1983).

    Google Scholar 

  57. K. S. Pang, H. Koster, I. C. M. Halsema, et al., J. Pharmacol. Exp. Ther.,224, 647–653 (1983).

    Google Scholar 

  58. K. S. Pang and R. N. Stillwell, J. Pharmacokinet. Biopharm.,11, 451–469 (1983).

    Google Scholar 

  59. K. S. Pang, W. F. Cherry, J. A. Terrell, and E. H. Ulm, Drug Metab. Dispos.,12, 309–313 (1984).

    Google Scholar 

  60. K. S. Pang, J. Pharmacokinet. Biopharm.,13, 633–662 (1985).

    Google Scholar 

  61. K. S. Pang, P. Kong, J. A. Terrell, and R. E. Billings, Drug Metab. Dispos.,13, 42–50 (1985).

    Google Scholar 

  62. K. S. Pang, J. A. Terrell, S. D. Nelson, et al., J. Pharmacokinet. Biopharm.,14, 107–130 (1986).

    Google Scholar 

  63. K. S. Pang, Top. Pharm. Sci. 1987; Proc. 47th Int. Contr. Amsterdam Aug. 31–Sept. 4, 1987, Amsterdam (1987), pp. 197–209.

  64. K. S. Pang, X. Xu. M. E. Morris, and V. Yuen, Fed. Proc,46, 2439–2441 (1987).

    Google Scholar 

  65. K. S. Pang, W. F. Cherry, J. Accaputo, et al., J. Pharmacol. Exp. Ther.,247, 690–700 (1988).

    Google Scholar 

  66. D. Perrier and M. Gibaldi, J. Pharmacol. Exp. Ther.,191, 17–24 (1974).

    Google Scholar 

  67. A. Rane, G. R. Wilkinson, and D. G. Shand, J. Pharmacol. Expt. Ther.,200, 420–424 (1977).

    Google Scholar 

  68. A. M. Rappaport, Microvasc. Res.,6, 212–228 (1973).

    Google Scholar 

  69. M. S. Roberts and M. Rowland, J. Pharm. Sci.,74, 585–587 (1985).

    Google Scholar 

  70. M. S. Roberts and M. Rowland, J. Pharm. Pharmacol.,38, 117–181 (1986).

    Google Scholar 

  71. M. S. Roberts, J. D. Donaldson, and D. Jackett, J. Pharmacokinet. Biopharm.,17, 687–719 (1989).

    Google Scholar 

  72. M. S. Roberts, S. Fraser, A. Wagner, and L. McLeod, J. Pharmacokinet. Biopharm.,18, 209–234 (1990).

    Google Scholar 

  73. M. S. Roberts, S. Fraser, W. A. Sharon, and L. McLeod, J. Pharmacokinet. Biopharm.,18, 235–258 (1990).

    Google Scholar 

  74. G. M. Rubin and T. N. Tozer, J. Pharm. Sci.,75, 660–663 (1986).

    Google Scholar 

  75. H. Sato, Y. Sugiyama, S. Miyauchi, et al., J. Pharm. Sci.,75, 3–8 (1986).

    Google Scholar 

  76. D. G. Shand, D. M. Kornhauser, and G. R. Wilkinson, J. Pharmacol. Exp. Ther.,195, 424–432 (1975).

    Google Scholar 

  77. R. J. St. Hilaire, G. T. Hradek, and A. L. Jones, Proc. Natl. Acad. Sci. USA,80, 3797–3801 (1983).

    Google Scholar 

  78. M. St. Pierre, D. Van Den Berg, and K. S. Pang, J. Pharmacokinet. Biopharm.,18, 423–448 (1990).

    Google Scholar 

  79. G. D. Sweeney, Trends Pharmacol. Sci.,2, 141–144 (1981).

    Google Scholar 

  80. R. G. Thurman and F. C. Kauffman, Hepatology,5, 144–151 (1985).

    Google Scholar 

  81. R. G. Thurman and J. J. Lemasters, Drug Metab. Rev.,19, 263–281 (1988).

    Google Scholar 

  82. G. R. Wilkinson, Pharmacol. Rev.,39, 1–47 (1987).

    Google Scholar 

  83. K. Winkler, L. Bass, S. Keiding, and N. Tygstrup, Scand. J. Gastroenterol.,14, 439–448 (1979).

    Google Scholar 

  84. E. Wojcik, C. Dvorak, J. Chianale, et al., J. Clin. Invest.,82, 658–666 (1988).

    Google Scholar 

  85. X. Xu and K. S. Pang, J. Pharmacokinet. Biopharm.,17, 645–671 (1989).

    Google Scholar 

  86. X. Xu, H. Hirayama, and K. S. Pang, Drug Metab. Dispos.,17, 556–563 (1989).

    Google Scholar 

  87. X. Xu, B. K. Tang, and K. S. Pang, J. Pharmacol. Exp. Ther.,253, 965–973 (1990).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Saratov Medical Institute, USSR

    A. N. Lutsevich & V. F. Kirichuk

Authors
  1. A. N. Lutsevich
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. F. Kirichuk
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated from Khimiko-farmatsevticheskii Zhurnal, Vol. 26, Nos. 11–12, pp. 22–28, November–December, 1992.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lutsevich, A.N., Kirichuk, V.F. Pharmacokinetic modeling of the elimination of drugs by the liver. II. Influence of the localization and activity of metabolizing enzymes and the rate of blood flow in the liver on the clearance of drugs (review). Pharm Chem J 26, 813–819 (1993). https://doi.org/10.1007/BF00767651

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00767651

Keywords

Search

Navigation