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Pharmaceutical Chemistry Journal

, Volume 1, Issue 6, pp 303–306 | Cite as

Synthesis of pyrimidine analogs of folic acid

  • V. M. Berezovskii
  • G. D. Glebova
  • E. M. Birinberg
  • N. A. Andreeva
Article

Abstract

In order to study their antimetabolic activity, we have synthesized the 2-methyl-4-amino-, 2,4-diamino-, 2,6-diamino-4-hydroxy-, and 2,4-dihydroxypyrimidine analogs of folic acid from p-aminobenzoyl-L-glutamic acid and the corresponding substituted 5-bromomethyl-pyrimidines. The high antimetabolic activity of the 2,4-dihydroxypyrimidine analog in the inhibition of the reductases of folic and dihydrofolic acids and of the 2,4-diaminopyrimidine analog in the inhibition of the reductase of dihydrofolic acid has been shown.

Keywords

Organic Chemistry Folic Acid Pyrimidine Pyrimidine Analog Dihydrofolic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Consultants Bureau 1968

Authors and Affiliations

  • V. M. Berezovskii
    • 1
  • G. D. Glebova
    • 1
  • E. M. Birinberg
    • 1
  • N. A. Andreeva
    • 1
  1. 1.All-Union Scientific Research Vitamin InstituteMoscow

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