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Biotechnology Techniques

, Volume 10, Issue 2, pp 99–102 | Cite as

Long-term cytotoxicities of various pesticides evaluated by albumin secretion of primary cultured rat hepatocytes

  • Kazuhiro Ichikawa
  • Yasuyuki Sakai
  • Akiyoshi Sakoda
  • Motoyuki Suzuki
Article

Summary

Primary cultured rat hepatocytes were used to estimate the cytotoxicities of various pesticides. The index was based on the inhibition of albumin secretion. Cytotoxicities closely correlated to the octanol/water distribution of pesticides. This estimation could be more reliable on the estimation of toxic effects on human health.

Keywords

Albumin Toxic Effect Albumin Secretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Ichikawa, K., Sakai, Y., Sakoda, A. and Suzuki, M. (1994)Biotechnol. Tech. 8, 385–388.Google Scholar
  2. Isenberg, D. L., “Ecotoxicology Monitoring,” ed. by Richardson, M., VCH Publ., Weinheim.(1993) pp. 3–15.Google Scholar
  3. Maron D. M. and Ames B. N. (1983).Mutation Res. 133, 173–186.Google Scholar
  4. Muraoka, S. and Yamanaka, S. (1982).Mutation Res.,102,13–26.Google Scholar
  5. Organization for Economic Cooperation and Development, “OECD Guidelines for Testing of Chemicals,” Nos. 201–210, 1993.Google Scholar
  6. Seglen PO (1976).Methods Biol. 13, 29–83.Google Scholar
  7. Suzuki M, Ichikawa K, Sakoda A and Sakai Y (1993).Cytotechnology.11, 213–218.PubMedGoogle Scholar
  8. US EPA : US Environment and Protection Agency Report on Suspect Carcinogens.Water Supply, Jun. 17 (1975)Google Scholar
  9. Utsumi, H., Hamada, A., Hayatsu, H., Hashimoto, T., and Aizawa, Y. (1990).Japan J. Water Pollu. Res.,1, 227–234.Google Scholar
  10. Verhaar, H. J. M., Van Leeuwen, C. J. and Hermens, L. M. (1992).Chemosphere. 2(4), 471–491.Google Scholar
  11. Wahlstrom, B.,Report No.8/1988, National Chemicals Inspectorate, Sweden.Google Scholar

Copyright information

© Chapman & Hall 1996

Authors and Affiliations

  • Kazuhiro Ichikawa
    • 1
  • Yasuyuki Sakai
    • 2
  • Akiyoshi Sakoda
    • 2
  • Motoyuki Suzuki
    • 2
  1. 1.Faculty of Pharmaceutical SciencesKyushu UniversityFukuokaJapan
  2. 2.Institute of Industrial Science, University of TokyoTokyoJapan

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