Pharmaceutical Chemistry Journal

, Volume 17, Issue 10, pp 685–693 | Cite as

Antiarrhythmic agents: Classification, structure, mechanism of action (review)

  • M. A. Dumpis
  • N. I. Kudryashova
Molecular-Biological Problems in the Creation of Drugs and Study of the Mechanism of Their Action


Organic Chemistry Antiarrhythmic Agent 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Literature cited

  1. 1.
    E. I. Chazov and V. I. Metelitsa, Khim.-farm. Zh., No. 10, 3–12 (1979).Google Scholar
  2. 2.
    E. J. Ariens, Progr. Pharm.,2, 1–6 (1979).Google Scholar
  3. 3.
    E. I. Chazov and V. M. Bogolyubov, Disturbances of the Hearth Rhythm [in Russian], Moscow (1972), pp. 18–37.Google Scholar
  4. 4.
    A. V. Sumarokov and A. A. Mikhailov, Cardiac Arrhythmia [in Russian], Moscow (1976), pp. 11–13.Google Scholar
  5. 5.
    L. Tomov and H. Tomov, Disturbances of the Heart Rhythm [in Russian], Sofia (1979), pp. 31–36.Google Scholar
  6. 6.
    L. Szekeres and G. J. Papp, Experimental Cardiac Arrhythmias and Antiarrhythmic Drugs, Budapest (1971), pp. 284–383.Google Scholar
  7. 7.
    B. N. Singh and O. Hausmirth, Am. Heart J.,87, 367–382 (1974).Google Scholar
  8. 8.
    W. E. M. Vaughan, Adv. Drug Res.,9, 69–76 (1974).Google Scholar
  9. 9.
    W. E. M. Vaughan, in: Symposium on Cardiac Arrhythmias (A. B. Astra, ed.), Sodertalje (1970), pp. 449–472.Google Scholar
  10. 10.
    L. S. Dreifus, I. M. De Azevedo, and Y. Watanabe, Am. Heart J.,88, 95–107 (1974).Google Scholar
  11. 11.
    P. F. Cranefield, The Conduction of the Cardiac Impulse — The Slow Response and Cardiac Arrhythmias, New York (1975), p. 404.Google Scholar
  12. 12.
    A. L. Basset and B. F. Huffman, Annu. Rev. Pharmacol.,11, 143 (1971).Google Scholar
  13. 13.
    M. R. Rosen and B. F. Huffman, Circulat. Res.,32, 1–8 (1973).Google Scholar
  14. 14.
    P. H. Morgan and I. W. Mathison, J. Pharm. Sci.,65, 467–482 (1976).Google Scholar
  15. 15.
    P. H. Morgan and I. W. Mathison, J. Pharm. Sci.,65, 635–648 (1976).Google Scholar
  16. 16.
    H. L. Conn, in: The Myocardial Cells: Structure, Function and Modification by Cardiac Drugs (S. R. Briller and H. L. Conn, eds.), Philadelphia (1966), pp. 269–296.Google Scholar
  17. 17.
    L. Tomov and Il. Tomov, Disturbances of the Hearth Rhythm [in Russian], Sofia (1979), pp. 323–325.Google Scholar
  18. 18.
    D. V. Godin, T. Au, and M. Garnet, in: International Congress of Pharmacology, 7th Abstracts, Paris (1978), p. 982.Google Scholar
  19. 19.
    P. T. Thyrum, H. L. Conn, and R. J. Luchi, Arch. Int. Pharmacodynam.,151, 494–503 (1964).Google Scholar
  20. 20.
    D. K. Young, M. M. Vohra, and I. Chu, J. Pharm. Pharmacol.,59, 1405–1409 (1970).Google Scholar
  21. 21.
    L. Szekeres and G. J. Papp, Experimental Cardiac Arrhythmias and Antiarrhythmic Drugs, Budapest (1971), p. 354.Google Scholar
  22. 22.
    E. W. Byrnes, P. D. McMaster, E. R. Smith, et al., J. Med. Chem.,22, 1179–1182 (1979).Google Scholar
  23. 23.
    P. A. Tenthorey, R. L. Dirubio, H. S. Feldman, et al., J. Med. Chem.,22, 1182–1187 (1979).Google Scholar
  24. 24.
    K. Van Dongen and A. Taal, Arch. Int. Pharmacodynam.,81, 129–147 (1969).Google Scholar
  25. 25.
    F. Alexander, H. Gold, N. L. Katz, et al., J. Pharmacol. Exp. Ther.,90, 191–198 (1947).Google Scholar
  26. 26.
    P. B. Hollander and H. R. Besch, Arch. Int. Pharmacodynam.,178, 407–411 (1969).Google Scholar
  27. 27.
    E. H. Yen, H. S. Lowrie, and R. R. Dean, J. Med. Chem.,17, 1131–1136 (1974).Google Scholar
  28. 28.
    M. D. Mashkovskii, Drugs [in Russian], Eighth Edition, Parts 1–2, Moscow (1977).Google Scholar
  29. 29.
    D. Hellenbrecht, Naunyn Schmiedeberg's Arch. Pharmacol.,271, 125–141 (1971).Google Scholar
  30. 30.
    B. Lemmer, G. Wiethold, D. Hellenbrecht, et al., Naunyn Schmiedeberg's Arch. Pharmacol.,275, 299–313 (1972).Google Scholar
  31. 31.
    G. Wiethold, D. Hellenbrecht, B. Lemmer, et al., Biochem. Pharmacol.,22, 1437–1449 (1973).Google Scholar
  32. 32.
    K. Hermansen, Br. J. Pharmacol.,35, 476–486 (1969).Google Scholar
  33. 33.
    W. G. Davis, J. Pharm. Pharmacol.,22, 284–290 (1970).Google Scholar
  34. 34.
    L. Tomov and Il. Tomov, Disturbances of the Heart Rhythm [in Russian], Sofia (1979), pp. 337–339.Google Scholar
  35. 35.
    B. R. Madan, S. N. Mischra, and V. K. Khanna, Arch. Int. Pharmacodynam.,182, 121–129 (1969).Google Scholar
  36. 36.
    A. M. Barret and V. A. Cullum, Br. J. Pharmacol.,34, 43–55 (1968).Google Scholar
  37. 37.
    R. Howe and R. G. Schanks, Nature,210, 1336–1338 (1966).Google Scholar
  38. 38.
    I. V. Komissarov, Drug Regulation of Adrenergic Processes [in Russian], Kiev (1976).Google Scholar
  39. 39.
    I. V. Komissarov, in: Brief Course in Molecular Pharmacology [in Russian], Moscow (1975), pp. 144–166.Google Scholar
  40. 40.
    R. Clarkson, H. Tucker, and J. Wale, Annu. Rep. Med. Chem.,10, 51–60 (1975).Google Scholar
  41. 41.
    H. Brunner, P. R. Hedwall, and M. Meiler, Naunyn Schmiedeberg's Arch. Pharmacol.,269, 219–231 (1971).Google Scholar
  42. 42.
    L. H. Smith, J. Appl. Chem. Biotechnol.,28, 201–212 (1978).Google Scholar
  43. 43.
    J. Y. Levy, J. Pharm. Pharmacol.,20, 813–818 (1968).Google Scholar
  44. 44.
    G. J. Kellicher and J. Roberts, Eur. J. Pharmacol.,20, 243–247 (1972).Google Scholar
  45. 45.
    I. De Vente, A. Bast, L. Van Bree, et al., Eur. J. Pharmacol.,63, 74–83 (1980).Google Scholar
  46. 46.
    E. J. Mylecharane and C. Raper, Arch. Int. Pharmacodynam.,202, 163–170 (1973).Google Scholar
  47. 47.
    M. L. Hoefle, S. G. Hasting, R. F. Meyer, et al., J. Med. Chem.,18, 148–152 (1975).Google Scholar
  48. 48.
    L. H. Smith and H. Tucker, J. Med. Chem.,20, 1653–1661 (1977).Google Scholar
  49. 49.
    B. N. Singh and E. W. Williams Vaughan, Br. J. Pharmacol.,39, 675–687 (1970).Google Scholar
  50. 50.
    F. W. Eichbaum and W. J. Iasaka, Br. J. Anaesth.,45, 1022–1028 (1973).Google Scholar
  51. 51.
    H. J. Sanders, Chem. Eng. News,60, 26–38 (1982).Google Scholar
  52. 52.
    M. R. Rosen, A. L. Wit, and B. F. Huffman, Am. Heart J.,89, 665–671 (1975).Google Scholar
  53. 53.
    V. I. Makolkin, I. S. Melkumova, and N. S. Zaitseva, Kardiologiya, No. 9, 116–120 (1981).Google Scholar
  54. 54.
    A. Fleckenstein, Annu. Rev. Pharmacol.,17, 149–166 (1977).Google Scholar
  55. 55.
    Knoll, Chem. Abstr.,59, 13892 (1963).Google Scholar
  56. 56.
    A. Fleckenstein, Adv. Cardiol.,12, 183–197 (1974).Google Scholar
  57. 57.
    A. Fleckenstein, in: Calcium and Heart (P. Harris, ed.), London (1971), pp. 32–81.Google Scholar
  58. 58.
    W. W. Tse and J. Han, Am. J. Cardiol.,36, 50–55 (1975).Google Scholar
  59. 59.
    H. J. Smith, B. N. Singh, and H. D. Nisbet, Cardiovasc. Res.,9, 569–578 (1975).Google Scholar
  60. 60.
    É. I. Gendenshtein, A. P. Tsybusov, L. N. Zhukauskaite, et al., Byull. Eksp. Biol. Med., No. 11, 55–57 (1982).Google Scholar
  61. 61.
    J. V. Levy, Eur. J. Pharmacol.,2, 250–257 (1968).Google Scholar
  62. 62.
    E. J. Ariens, Ann. N. Y. Acad. Sci.,139, 606–631 (1967).Google Scholar
  63. 63.
    D. Hellenbrecht, B. Lemmer, G. Wiethold, et al., Naunyn Schmiedeberg's Arch. Pharmacol.,277, 211–226 (1973).Google Scholar
  64. 64.
    J. Zaagsma and W. Th. Nauta, J. Med. Chem.,17, 507–513 (1974).Google Scholar
  65. 65.
    I. W. Mathison and R. C. Gueldner, J. Org. Chem.,33, 2510–2512 (1968).Google Scholar
  66. 66.
    I. W. Mathison, R. C. Gueldner, J. W. Lawson, et al., J. Med. Chem.,11, 997–1000 (1968).Google Scholar
  67. 67.
    I. W. Mathison and P. H. Morgan, J. Med. Chem.,17, 1136–1140 (1974).Google Scholar
  68. 68.
    I. W. Mathison and R. R. Tidwell, J. Med. Chem.,18, 1227–1231 (1975).Google Scholar
  69. 69.
    E. H. Yen, H. S. Lowrie, and R. R. Dean, J. Med. Chem.,17, 1131–1136 (1974).Google Scholar
  70. 70.
    F. Hackenberger, Pharmazie,38, 491–500 (1979).Google Scholar

Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • M. A. Dumpis
    • 1
  • N. I. Kudryashova
    • 1
  1. 1.Scientific-Research Institute of Experimental MedicineAcademy of Medical Sciences of the USSRLeningrad

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