Catalysis Letters

, Volume 6, Issue 3–6, pp 281–288 | Cite as

Role of the modifier in the enantioselective hydrogenation of ethyl pyruvate over Pt/Al2O3 catalyst

  • J. L. Margitfalvi
  • P. Marti
  • A. Baiker
  • L. Botz
  • O. Sticher
Article

Abstract

The time dependence of the conversion and enantioselectivity during the hydrogenation of ethyl pyruvate has been studied over an industrial Pt/Al2O3 catalyst. Various cinchona alkaloids were used as modifier and two different modes were applied for their introduction into the reaction system. The dependence of the enantioselectivity on conversion is strongly influenced by the mode of introduction and the structure of the modifier used. The conversion dependence of the enantioselectivity is attributed to the chemical transformations of the parent alkaloid observed under hydrogenation conditions. Experimental evidence is shown for the dynamic nature of the interaction between the modifier and the catalyst.

Enantioselective hydrogenation ethyl pyruvate Pt/Al2O3 cinchona alkaloids modifier 

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Copyright information

© J.C. Baltzer A.G. Scientific Publishing Company 1990

Authors and Affiliations

  • J. L. Margitfalvi
    • 1
  • P. Marti
    • 1
  • A. Baiker
    • 1
  • L. Botz
    • 2
  • O. Sticher
    • 2
  1. 1.Department of Industrial and Engineering ChemistrySwiss Federal Institute of TechnologySwitzerland
  2. 2.Department of PharmacySwiss Federal Institute of TechnologyZürichSwitzerland

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