Journal of Bioenergetics and Biomembranes

, Volume 26, Issue 2, pp 173–178 | Cite as

The mitochondrial ATP synthase ofTrypanosoma brucei: Structure and regulation

  • Noreen Williams
Article

Abstract

The structure and regulation of theTrypanosoma brucei mitochondrial ATP synthase is reviewed. This enzyme complex which catalyzes the synthesis and hydrolysis of ATP within the mitochondrion is a multisubunit complex which is regulated in several ways. Several lines of evidence have shown that the ATP synthase is regulated through the life cycle ofTrypanosoma brucei. The enzyme complex is present at maximal levels in the procyclic form where mitochondrial activity is the highest and cytochromes and Kreb's cycle components are present. The levels of the ATP synthase are decreased in the bloodstream forms where the levels of the mitochondrial cytochromes are absent or substantially decreased. In recent preliminary work we have shown the presence of an ATP synthase inhibitor peptide which may indicate an additional level of complexity to the regulation.

Key words

ATP synthase Trypansoma regulation inhibitor peptide 

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References

  1. Allison, W. S., Jault, J.-M., Zhuo, S., and Paik, S. R. (1992).J. Bioenerg. Biomembr. 24 469–477.Google Scholar
  2. Asami, K., Juntii, K., and Ernster, L. (1970).Biochim. Biophys. Acta 205 307–311.Google Scholar
  3. Benne, R., Van den Berg, J., Brackenhoff, J. P. J., Sloof, P., Van Boom, J. H., and Tromp, M. C. (1986).Cell 46 819–826.Google Scholar
  4. Bowman, I. B. R., and Flynn, I. W. (1973). InBiology of the Kinetoplastida (Lumsden, W. H. R., and Evans, D. A., eds.), Academic Press, New York, Vol. 1, pp. 433–476.Google Scholar
  5. Bhar, G. J., Koslowsky, D. J., Feagin, J. E., Smiley, B. L., and Stuart, K. (1990).Cell 61 885–894.Google Scholar
  6. Bienen, E. J., Hammadi, E., and Hill, G. C. (1981).Exp. Parasitol. 51 408–417.Google Scholar
  7. Bienen, E. J., Saric, M., Pollakis, G., Grady, R. W., and Clarkson, A. B. (1991).Mol. Biochem. Parasitol. 45 185–192.Google Scholar
  8. Cataldi de Flombaum, M. A., Frasch, A. C. C., and Stoppani, A. O. M. (1980).Comp. Biochem. Physiol. 65B 103–109.Google Scholar
  9. Cintron, N. M., and Pedersen, P. L. (1979).J. Biol. Chem. 254 3439–3443.Google Scholar
  10. Cross, R. L. (1988)J. Bioenerg. Biomemb. 20 395–405.Google Scholar
  11. Feagin, J. E. (1990).J. Biol. Chem. 265 19373–19376.Google Scholar
  12. Feagin, J. E., and Stuart, K. E. (1988).Mol. Cell. Biol. 8 1259–1265.Google Scholar
  13. Fillingame, R. H. (1990). InThe Bacteria, Academic Press, New York, Vol. XII, pp. 345–391.Google Scholar
  14. Fillingame, R. H. (1992).J. Bioenerg. Biomembr. 24 485–491.Google Scholar
  15. Fujii, S., Hashimoto, T., Yoshida, Y., Miura, R., Yamano, T., and Tagawa, K. (1983)J. Biochem. 93 189–196.Google Scholar
  16. Futai, M., Noumi, T., and Maeda, M. (1989).Annu. Rev. Biochem. 58 111–136.Google Scholar
  17. Gromet-Elthanan, Z. (1992).J. Bioenerg. Biomembr. 24 447–452.Google Scholar
  18. Hajduk, S. L., Harris, M. E., and Pollard, V. W. (1993).FASEB J. 7 54–63.Google Scholar
  19. Hashimoto, T., Yoshida, Y., and Tagawa, K. (1990).J. Bioenerg. Biomembr. 22 27–38.Google Scholar
  20. Higa, A. I., and Cazzulo, J. J. (1981).Mol. Biochem. Parasitol. 3 357–367.Google Scholar
  21. Michelotti, E. F., and Hajduk, S. L. (1987).J. Biol. Chem. 262 927–932.Google Scholar
  22. Mimura, H., Hashimoto, T., Yoshida, Y., Ichikawa, N., and Tagawa, K. (1993).J. Biochem. 113 350–354.Google Scholar
  23. Nolan, D. P., and Voorheis, H. P. (1992).Eur. J. Biochem. 209 207–216.Google Scholar
  24. Nolan, D. P., and Voorheis, H. P. (1990).Biochem. Soc. Trans. 18 735–739.Google Scholar
  25. Opperdoes, F. R., Borst, P., and de Rijke, D. (1976a).Comp. Biochem. Physiol. 55B 25–30.Google Scholar
  26. Opperdoes, F. R., DeRijke, D., and Borst, P. (1976b).Comp. Biochem. Physiol. 54B 7–12.Google Scholar
  27. Opperdoes, F. R., Borst, P., and Spits, H. (1977).Eur. J. Biochem. 76 229–237.Google Scholar
  28. Pedersen, P. L., and Carafoli, E. (1987).Trends Biochem. Sci. 12 146–189.Google Scholar
  29. Penefsky, H. S., and Cross, R. L. (1991). InAdvances in Enzymology and Related Areas of Molecular Biology, Wiley, New York, Vol. 64, pp. 173–214.Google Scholar
  30. Perlin, D. S., Latchney, L. R., and Senior, A. E. (1985).Biochim. Biophys. Acta 807 238–244.Google Scholar
  31. Pullman, M. E., and Monroy, G. C. (1963).J. Biol. Chem. 238 3762–3769.Google Scholar
  32. Rassam, M. R., and Robert, Z. J. (1988).Mol. Biochem. Parasitol. 29 153–158.Google Scholar
  33. Rohrer, S. P., Michelotti, E. F., Torri, A. F., and Hajduk, S. L. (1987).Cell 49 625–632.Google Scholar
  34. Schwerzmann, K., and Pedersen, P. L. (1986).Arch. Biochem. Biophys. 250 1–18.Google Scholar
  35. Senior, A. E. (1979).J. Biol. Chem. 254 11319–11322.Google Scholar
  36. Senior, A. E. (1990).Annu. Rev. Biophys. Biophys. Chem. 19 7–41.Google Scholar
  37. Senior, A. E. (1992),J. Bioenerg. Biomembr. 24 479–484.Google Scholar
  38. Soper, J. W., Decker, G. L., and Pedersen, P.L. (1979).J. Biol. Chem. 254 11170–11176.Google Scholar
  39. Torri, A. F., and Hajduk, S. L. (1988).Mol. Cell. Biol. 8 4625–4633.Google Scholar
  40. Tuena de Gomez-Puyou, M., Martins, O. B., and Gomez-Puyou, A. (1988).Biochem. Cell Biol. 66 677–682.Google Scholar
  41. Vickerman, K. (1965).Nature (London) 208 762–766.Google Scholar
  42. Williams, N., and Frank, P. H. (1990).Mol. Biochem. Parasitol. 43 125–132.Google Scholar
  43. Williams, N., Hullihen, J., and Pedersen, P. L. (1987).Biochemistry 26 162–169.Google Scholar
  44. Williams, N., Choi, S. Y.-W., Ruyechan, W., and Frank, P. (1991).Arch. Biochem. Biophys. 288 509–515.Google Scholar
  45. Yamada, E., and Huzel, N. J. (1988).J. Biol. Chem. 263 11498–11503.Google Scholar
  46. Yarlett, N., and Lloyd, D. (1981).Mol. Biochem. Parasitol. 3 13–17.Google Scholar

Copyright information

© Plenum Publishing Corporation 1994

Authors and Affiliations

  • Noreen Williams
    • 1
  1. 1.Department of MicrobiologyState University of New York at BuffaloBuffalo

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