Journal of Bioenergetics and Biomembranes

, Volume 26, Issue 2, pp 173–178 | Cite as

The mitochondrial ATP synthase ofTrypanosoma brucei: Structure and regulation

  • Noreen Williams


The structure and regulation of theTrypanosoma brucei mitochondrial ATP synthase is reviewed. This enzyme complex which catalyzes the synthesis and hydrolysis of ATP within the mitochondrion is a multisubunit complex which is regulated in several ways. Several lines of evidence have shown that the ATP synthase is regulated through the life cycle ofTrypanosoma brucei. The enzyme complex is present at maximal levels in the procyclic form where mitochondrial activity is the highest and cytochromes and Kreb's cycle components are present. The levels of the ATP synthase are decreased in the bloodstream forms where the levels of the mitochondrial cytochromes are absent or substantially decreased. In recent preliminary work we have shown the presence of an ATP synthase inhibitor peptide which may indicate an additional level of complexity to the regulation.

Key words

ATP synthase Trypansoma regulation inhibitor peptide 


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Copyright information

© Plenum Publishing Corporation 1994

Authors and Affiliations

  • Noreen Williams
    • 1
  1. 1.Department of MicrobiologyState University of New York at BuffaloBuffalo

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