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Protein phosphorylation associated with the stimulation of neutrophils. Modulation of superoxide production by protein kinase C and calcium

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Abstract

Neutrophils and other phagocytic cells of the immune system possess a superoxide-generating oxidase system which is essential for the efficient killing of microbes. The system is activated by a wide variety of stimuli, some of which operate through pathways involving protein kinase C (PKC), while others appear not to. The PKC-dependent pathway is probably the major signal transduction route for most of the stimuli. Alterations in cellular Ca2+ and diglyceride levels can have a pronounced stimulatory effect on this pathway by their ability to synergistically activate PKC. This review discusses PKC, the different interactions of this kinase with the plasmalemma that are important in superoxide production, the synergy between Ca2+ and diglyceride, and the nature of the phosphoproteins involved. Evidence supporting the existence of the PKC-independent pathway is also reviewed.

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References

  • Babior, B. (1988).Arch. Biochem. Biophys. 264, 361–367.

    Google Scholar 

  • Babior, B. M., Kuver, R., and Curnutte, J. T. (1988).J. Biol. Chem. 263, 1713–1718.

    Google Scholar 

  • Badwey, J. A., and Karnovsky, M. L. (1980).Annu. Rev. Biochem. 49, 695–726.

    Google Scholar 

  • Badwey, J. A., and Karnovsky, M. L. (1986).Curr. Top. Cell. Regul. 28, 183–208.

    Google Scholar 

  • Badwey, J. A., Curnutte, J. T., Robinson, J. M., Berde, C. B., Karnovsky, M. J., and Karnovsky, M. L. (1984).J. Biol. Chem. 259, 7870–7877.

    Google Scholar 

  • Badwey, J. A., Robinson, J. M., Curnutte, J. T., Karnovsky, M. J., and Karnovsky, M. L. (1986).J. Cell. Physiol. 127, 223–228.

    Google Scholar 

  • Badwey, J. A., Robinson, J. M., Horn, W., Soberman, R. J., Karnovsky, M. J., and Karnovsky, M. L. (1988).J. Biol. Chem. 263, 2779–2786.

    Google Scholar 

  • Badwey, J. A., Heyworth, P. G., and Karnovsky, M. L. (1989a).Biochem. Biophys. Res. Commun. 158, 1029–1035.

    Google Scholar 

  • Badwey, J. A., Horn, W., Heyworth, P. G., Robinson, J. M., and Karnovsky, M. L. (1989b).J. Biol. Chem. 264, 14947–14953.

    Google Scholar 

  • Badwey, J. A., Robinson, J. M., Heyworth, P. G., and Curnutte, J. T. (1989c).J. Biol. Chem. 264, 20676–20682.

    Google Scholar 

  • Bass, D. A., Gerard, C., Olbrantz, P., Wilson, J., McCall, C. E., and McPhail, L. C. (1987).J. Biol. Chem. 262, 6643–6649.

    Google Scholar 

  • Bass, D. A., McPhail, L. C., Schmitt, J. D., Morris-Natschke, S., McCall, C. E., and Wykle, R. L. (1988).J. Biol. Chem. 263, 19610–19617.

    Google Scholar 

  • Bazzi, M. D., and Nelsestuen, G. L. (1987).Biochemistry 26, 5002–5008.

    Google Scholar 

  • Bazzi, M. D., and Nelsestuen, G. L. (1988).Biochemistry 27, 7589–7593.

    Google Scholar 

  • Bazzi, M. D., and Nelsestuen, G. L. (1989).Biochemistry 28, 3577–3585.

    Google Scholar 

  • Bellavite, P., Corso, F., Dusi, S., Grzeskowiak, M., Della-Bianca, V., and Rossi, F. (1988).J. Biol. Chem. 263, 8210–8214.

    Google Scholar 

  • Berridge, M. F., and Irvine, R. F. (1984).Nature (London)312, 315–321.

    Google Scholar 

  • Billah, M. M., and Siegel, M. I. (1987).Biochem. Biophys. Res. Commun. 144, 683–691.

    Google Scholar 

  • Bolscher, B. G. J. M., van Zwieten, R., Kramer, I. M., Weening, R. S., Verhoeven, A. J., and Roos, D. (1989).J. Clin. Invest. 83, 757–763.

    Google Scholar 

  • Borregaard, N. (1988).J. Bioenerg. Biomembr. 20, 637–651.

    Google Scholar 

  • Burnham, D. N., Tyagi, S. R., Uhlinger, D. J., and Lambeth, J. D. (1989).Arch. Biochem. Biophys. 269, 345–353.

    Google Scholar 

  • Caldwell, S. E., McCall, C. E., Hendricks, C. L., Leone, P. A., Bass, D. A., and McPhail, L. C. (1988).J. Clin. Invest. 81, 1485–1496.

    Google Scholar 

  • Castagna, M., Takai, Y., Kaibuchi, K., Sano, K., Kikkawa, U., and Nishizuka, Y. (1982).J. Biol. Chem. 257, 7847–7851.

    Google Scholar 

  • Christiansen, N. O., Peterslund, N. A., Larsen, C. S., and Esmann, V. (1987).Biochem. Biophys. Res. Commun. 147, 787–793.

    Google Scholar 

  • Clark, R. A., Leidal, K. G., Pearson, D. W., and Nauseef, W. M. (1987).J. Biol. Chem. 262, 4065–4074.

    Google Scholar 

  • Clark, R. A., Volpp, B. D., Leidal, K. G., and Nauseef, W. M. (1989).Clin. Res. 37, 607A (abstract).

  • Cohen, P. (1988).Proc. R. Soc. London B 234, 115–144.

    Google Scholar 

  • Cox, C. C., Dougherty, R. W., Ganong, B. R., Bell, R. M., Niedel, J. E., and Snyderman, R. (1986).J. Immunol. 136, 4611–4616.

    Google Scholar 

  • Cox, J. A., Jeng, A. Y., Blumberg, P. M., and Tauber, A. I. (1987).J. Immunol. 138, 1884–1888.

    Google Scholar 

  • Curnutte, J. T. (1985).J. Clin. Invest. 75, 1740–1743.

    Google Scholar 

  • Curnutte, J. T. (1988).Hematol. Oncol. Clin. N. Am. 2, 241–252.

    Google Scholar 

  • Curnutte, J. T., and Babior, B. M. (1987).Adv. Human Genet. 16, 229–297.

    Google Scholar 

  • Curnutte, J. T., Badwey, J. A., Robinson, J. M., Karnovsky, M. J., and Karnovsky, M. L. (1984).J. Biol. Chem. 259, 11851–11857.

    Google Scholar 

  • Curnutte, J. T., Kuver, R., and Scott, P. J. (1987).J. Biol. Chem. 262, 5563–5569.

    Google Scholar 

  • Curnutte, J. T., Scott, P. J., and Mayo, L. A. (1989).Proc. Natl. Acad. Sci. USA 86, 825–829.

    Google Scholar 

  • Dell, K. R., Walsh, M. P., and Severson, D. L. (1988).Biochem. J. 254, 455–462.

    Google Scholar 

  • Dewald, B., Thelen, M., and Baggiolini, M. (1988).J. Biol. Chem. 263, 16179–16184.

    Google Scholar 

  • Dinauer, M. C., Orkin, S. H., Brown, R., Jesaitis, A. J., and Parkos, C. A. (1987).Nature (London)327, 717–720.

    Google Scholar 

  • Dinauer, M. C., Orkin, S. H., Hurst, J. K., Parkos, C. A., Jesaitis, A. J., Rosen, H., and Curnutte, J. T. (1989).Clin. Res. 37, 544A (abstract).

  • DiVirgilio, F., Lew, P. D., and Pozzan, T. (1984).Nature (London)310, 691–693.

    Google Scholar 

  • Dougherty, R. W., and Niedel, J. E. (1986).J. Biol. Chem. 261, 4097–4100.

    Google Scholar 

  • Dougherty, R. W., Dubay, G. R., and Niedel, J. E. (1989).J. Biol. Chem. 264, 11263–11269.

    Google Scholar 

  • Edelman, A. M., Blumenthal, D. K., and Krebs, E. G. (1987).Annu. Rev. Biochem. 56, 567–614.

    Google Scholar 

  • Finkel, T. H., Pabst, M. J., Suzuki, H., Guthrie, L. A., Forehand, J. R., Phillips, W. A., and Johnston, R. B. (1987).J. Biol. Chem. 262, 12589–12596.

    Google Scholar 

  • Ford, D. A., Miyake, R., Glaser, P. E., and Gross, R. W. (1989).J. Biol. Chem. 264, 13818–13824.

    Google Scholar 

  • Gabig, T. G., English, D., Akard, L. P., and Schell, M. J. (1987).J. Biol. Chem. 262, 1685–1690.

    Google Scholar 

  • Garcia, R. C., and Segal, A. W. (1988).Biochem. J. 252, 901–904.

    Google Scholar 

  • Gomez-Cambronero, J., Huang, C-K., Bonak, V. A., Wang, E., Casnellie, J. E., Shiraishi, T., and Sha'afi, R. I. (1989).Biochem. Biophys. Res. Commun. 162, 1478–1485.

    Google Scholar 

  • Grand, R. J. A. (1989).Biochem. J. 258, 625–638.

    Google Scholar 

  • Hamilton, T. A., Becton, D. L., Somers, S. D., Gray, P. W., and Adams, D. O. (1985).J. Biol. Chem. 260, 1378–1381.

    Google Scholar 

  • Hannun, Y. A., Loomis, C. R., Merrill, A. H., and Bell, R. M. (1986a).J. Biol. Chem. 261, 12604–12609.

    Google Scholar 

  • Hannun, Y. A., Loomis, C. R., and Bell, R. M. (1986b).J. Biol. Chem. 261, 7184–7190.

    Google Scholar 

  • Helfman, D. M., Appelbaum, B. D., Vogler, W. R., and Kuo, J. F. (1983).Biochem. Biophys. Res. Commun. 111, 847–853.

    Google Scholar 

  • Heyworth, P. G., and Segal, A. W. (1986).Biochem. J. 239, 723–731.

    Google Scholar 

  • Heyworth, P. G., Karnovsky, M. L., and Badwey, J. A. (1989a).J. Biol. Chem. 264, 14935–14939.

    Google Scholar 

  • Heyworth, P. G., Shrimpton, C. F., and Segal, A. W. (1989b).Biochem. J. 260, 243–248.

    Google Scholar 

  • Hidaka, H., Inagaki, M., Kawamoto, S., and Sasaki, Y. (1984).Biochemistry 23, 5036–5041.

    Google Scholar 

  • Horn, W., and Karnovsky, M. L. (1986).Biochem. Biophys. Res. Commun. 139, 1169–1175.

    Google Scholar 

  • House, C., and Kemp, B. E. (1987).Science 238, 1726–1728.

    Google Scholar 

  • House, C., Wettenhall, R. E. H., and Kemp, B. E. (1987).J. Biol. Chem. 262, 772–777.

    Google Scholar 

  • Huang, C-K, and Laramee, G. F. (1988).J. Biol. Chem. 263, 13144–13151.

    Google Scholar 

  • Huang, C-K., Laramee, G. R., and Casnellie, J. E. (1988).Biochem. Biophys. Res. Commun. 151, 794–801.

    Google Scholar 

  • Hunter, T., and Cooper, J. A. (1985).Annu. Rev. Biochem. 54, 897–930.

    Google Scholar 

  • Inoue, M., Kishimoto, A., Takai, Y., and Nishizuka, Y. (1977).J. Biol. Chem. 252, 7610–7616.

    Google Scholar 

  • Jefferson, A. B., and Schulman, H. (1988).J. Biol. Chem. 263, 15241–15244.

    Google Scholar 

  • Jesaitis, A. J., and Allen, R. A. (1988).J. Bioenerg. Biomembr. 20, 679–707.

    Google Scholar 

  • Kase, H., Iwahashi, K., Nakanishi, S., Matsuda, Y., Yamada, K., Takahashi, M., Murakata, C., Sato, A., and Kaneko, M. (1987).Biochem. Biophys. Res. Commun. 142, 436–440.

    Google Scholar 

  • Kensler, T. W., and Mueller, G. C. (1978).Cancer Res. 38, 771–775.

    Google Scholar 

  • Kensler, T. W., and Trush, M. A. (1981).Cancer Res. 41, 216–222.

    Google Scholar 

  • Kikkawa, U., Takai, Y., Tanaka, T., Miyake, R., and Nishizuka, Y. (1983).J. Biol. Chem. 258, 11442–11445.

    Google Scholar 

  • Kojima, I., Kojima, K., and Rasmussen, H. (1985).J. Biol. Chem. 260, 9177–9184.

    Google Scholar 

  • Korchak, H. M., Vosshall, L. B., Haines, K. A., Wilkenfeld, C., Lindquist, K. F., and Weissman, G. (1988).J. Biol. Chem. 263, 11098–11105.

    Google Scholar 

  • Kraft, A. S., and Berkow, R. L. (1987).Blood 70, 356–362.

    Google Scholar 

  • Kramer, I. M., van der Bend, R. L., Verhoeven, A. J., and Roos, D. (1988a).Biochim. Biophys. Acta 971, 189–196.

    Google Scholar 

  • Kramer, I. M., Verhoeven, A. J., van der Bend, R. L., Weening, R. S., and Roos, D. (1988b).J. Biol. Chem. 263, 2352–2357.

    Google Scholar 

  • Kramer, I. M., van der Bend, R. L., Tool, A. T. J., van Blitterswijk, W. J., Roos, D., and Verhoeven, A. J. (1989).J. Biol. Chem. 264, 5876–5884.

    Google Scholar 

  • Lambeth, J. D. (1988).J. Bioenerg. Biomembr. 20, 709–733.

    Google Scholar 

  • Lambeth, J. D., Burnham, D. N., and Tyagi, S. R. (1988).J. Biol. Chem. 263, 3818–3822.

    Google Scholar 

  • Ligeti, E., Doussiere, J., and Vignais, P. V. (1988).Biochemistry 27, 193–200.

    Google Scholar 

  • Ligeti, E., Tardiff, M., and Vignais, P. V. (1989).Biochemistry 28, 7116–7123.

    Google Scholar 

  • Lochner, J. E., Badwey, J. A., Horn, W., and Karnovsky, M. L. (1986).Proc. Natl. Acad. Sci. USA 83, 7673–7677.

    Google Scholar 

  • Lomax, K. J., Leto, T. L., Nunoi, H., Gallin, J. I., and Malech, H. L. (1989).Science 245, 409–412.

    Google Scholar 

  • May, W. S., Sahyoun, N., Wolf, M., and Cuatrecasas, P. (1985).Nature (London)317, 549–551.

    Google Scholar 

  • May, W. S., Lapetina, E. G., and Cuatrecasas, P. (1986).Proc. Natl. Acad. Sci. USA 83, 1281–1284.

    Google Scholar 

  • McColl, S. R., Hurst, N. P., and Cleland, L. G. (1986).Biochem. Biophys. Res. Commun. 141, 399–404.

    Google Scholar 

  • McColl, S. R., Hurst, N. P., Betts, W. H., and Cleland, L. G. (1987).Biochem. Biophys. Res. Commun. 147, 622–626.

    Google Scholar 

  • McIntyre, T. M., Reinhold, S. L., Prescott, S. M., and Zimmerman, G. A. (1987).J. Biol. Chem. 262, 15370–15376.

    Google Scholar 

  • McPhail, L. C., Clayton, C. C., and Snyderman, R. (1984).J. Biol. Chem. 259, 5768–5775.

    Google Scholar 

  • McPhail, L. C., Shirley, P. S., Clayton, C. C., and Snyderman, R. (1985).J. Clin. Invest. 75, 1735–1739.

    Google Scholar 

  • Melloni, E., Pontremoli, S., Michetti, M., Sacco, O., Sparatore, B., Salamino, F., and Horecker, B. L. (1985).Proc. Natl. Acad. Sci. USA 82, 6435–6439.

    Google Scholar 

  • Melloni, E., Pontremoli, S., Michetti, M., Sacco, O., Sparatore, B., and Horecker, B. L. (1986).J. Biol. Chem. 261, 4101–4105.

    Google Scholar 

  • Naka, M., Nishikawa, M., Adelstein, R. S., and Hidaka, H. (1983).Nature (London)306, 490–493.

    Google Scholar 

  • Nath, J., Powledge, A., and Wright, D. G. (1989).J. Biol. Chem. 264, 848–855.

    Google Scholar 

  • Nauseef, W. M., Volpp, B. D., and Clark, R. A. (1988).J. Cell Biol. 107, 57a (abstract).

  • Nishihira, J., and O'Flaherty, J. T. (1985).J. Immunol. 135, 3439–3447.

    Google Scholar 

  • Nishizuka, Y. (1984).Science 225, 1365–1370.

    Google Scholar 

  • Nunoi, H., Rotrosen, D., Gallin, J. I., and Malech, H. L. (1988).Science 242, 1298–1301.

    Google Scholar 

  • O'Flaherty, J. T., and Nishihira, J. (1987).Biochem. Biophys. Res. Commun. 148, 575–581.

    Google Scholar 

  • O'Flaherty, J. T., Schmitt, J. D., and Wykle, R. L. (1985).Biochem. Biophys. Res. Commun. 127, 916–923.

    Google Scholar 

  • Ohta, H., Okajima, F., and Ui, M. (1985).J. Biol. Chem. 260, 15771–15780.

    Google Scholar 

  • Ohtsuka, T., Okamura, N., and Ishibashi, S. (1986).Biochim. Biophys. Acta 888, 332–337.

    Google Scholar 

  • Okamura, N., Ohashi, S., Nagahisa, N., and Ishibashi, S. (1984).Arch. Biochem. Biophys. 228, 270–277.

    Google Scholar 

  • Okamura, N., Curnutte, J. T., Roberts, R. L., and Babior, B. M. (1988a).J. Biol. Chem. 263, 6777–6782.

    Google Scholar 

  • Okamura, N., Malawista, S. E., Roberts, R. L., Rosen, H., Ochs, H. D., Babior, B. M., and Curnutte, J. T. (1988b).Blood 72, 811–816.

    Google Scholar 

  • Pai, J-K., Siegel, M. I., Egan, R. W., and Billah, M. M. (1988a).J. Biol. Chem. 263, 12472–12477.

    Google Scholar 

  • Pai, J-K., Siegel, M. I., Egan, R. W., and Billah, M. M. (1988b).Biochem. Biophys. Res. Commun. 150, 355–364.

    Google Scholar 

  • Parkinson, J. F., and Gabig, T. G. (1988).J. Bioenerg. Biomembr. 20, 653–677.

    Google Scholar 

  • Parkos, C. A., Allen, R. A., Cochrane, C. G., and Jesaitis, A. J. (1987).J. Clin. Invest. 80, 732–742.

    Google Scholar 

  • Parkos, C. A., Dinauer, M. C., Walker, L. E., Allen, R. A., Jesaitis, A. J., and Orkin, S. H. (1988).Proc. Natl. Acad. Sci. USA 85, 3319–3323.

    Google Scholar 

  • Penfield, A., and Dale, M. M. (1984).Biochem. Biophys. Res. Commun. 125, 332–336.

    Google Scholar 

  • Phillips, W. A., and Hamilton, J. A. (1989).J. Immunol. 142, 2445–2449.

    Google Scholar 

  • Phillips, W. A., Fujiki, T., Rossi, M. W., Korchak, H. M., and Johnston, R. B. (1989).J. Biol. Chem. 264, 8361–8365.

    Google Scholar 

  • Pontremoli, S., Melloni, E., Michetti, M., Sacco, O., Sparatore, B., Salamino, F., Damiani, G., and Horecker, B. L. (1986a).Proc. Natl. Acad. Sci. USA 83, 1685–1689.

    Google Scholar 

  • Pontremoli, S., Melloni, E., Salamino, F., Sparatore, B., Michetti, M., Sacco, O., and Horecker, B. L. (1986b).Arch. Biochem. Biophys. 250, 23–29.

    Google Scholar 

  • Pontremoli, S., Melloni, E., Michetti, M., Sacco, O., Salamino, F., Sparatore, B., and Horecker, B. L. (1986c).J. Biol. Chem. 261, 8309–8313.

    Google Scholar 

  • Pozzan, T., Lew, P. D., Wollheim, C. B., and Tsien, R. Y. (1983).Science 221, 1413–1415.

    Google Scholar 

  • Repine, J. E., White, J. G., Clawson, C. C., and Holmes, B. M. (1974).J. Lab. Clin. Med. 83, 911–920.

    Google Scholar 

  • Restrepo, D., Kozody, D. J., and Knauf, P. A. (1989).J. Biol. Chem. 264, 776–781.

    Google Scholar 

  • Rider, L. G., and Niedel, J. E. (1987).J. Biol. Chem. 262, 5603–5608.

    Google Scholar 

  • Robinson, J. M., Badwey, J. A., Karnovsky, M. L., and Karnovsky, M. J. (1984).Biochem. Biophys. Res. Commun. 122, 734–739.

    Google Scholar 

  • Robinson, J. M., Badwey, J. A., Karnovsky, M. L., and Karnovsky, M. J. (1985).J. Cell Biol. 101, 1052–1058.

    Google Scholar 

  • Rotrosen, D., Nunoi, H., Gallin, J. I., and Malech, H. L. (1989).Clin. Res. 37, 438A (abstract).

  • Royer-Pokora, B., Kunkel, L. M., Monaco, A. P., Goff, S. C., Newburger, P. E., Baehner, R. L., Cole, F. S., Curnutte, J. T., and Orkin, S. H. (1986).Nature (London)322, 32–38.

    Google Scholar 

  • Schneider, C., Zanetti, M., and Romeo, D. (1981).FEBS Lett. 127, 4–8.

    Google Scholar 

  • Segal, A. W. (1987).Nature (London)326, 88–91.

    Google Scholar 

  • Segal, A. W., and Jones, O. T. G. (1980).FEBS Lett. 110, 111–114.

    Google Scholar 

  • Segal, A. W., Heyworth, P. G., Cockcroft, S., and Barrowman, M. M. (1985).Nature (London)316, 547–549.

    Google Scholar 

  • Tanaka, T., Makino, R., Iizuka, T., Ishimura, Y., and Kanegasaki, S. (1988).J. Biol. Chem. 263, 13670–13676.

    Google Scholar 

  • Tauber, A. I. (1987).Blood 69, 711–720.

    Google Scholar 

  • Teahan, C., Rowe, P., Parker, P., Totty, N., and Segal, A. W. (1987).Nature (London)327, 720–721.

    Google Scholar 

  • Tettenhorn, S. C., and Mueller, G. C. (1988).Biochem. Biophys. Res. Commun. 155, 249–255.

    Google Scholar 

  • Traynor, A. E., Scott, P. J., Hariss, A. L., Badwey, J. A., Sklar, L. A., Babior, B. M., and Curnutte, J. T. (1989).Blood 73, 296–300.

    Google Scholar 

  • Tyagi, S. R., Tamura, M., Burnham, D. N., and Lambeth, J. D. (1988).J. Biol. Chem. 263, 13191–13198.

    Google Scholar 

  • Tyagi, S. R., Burnham, D. N., and Lambeth, J. D. (1989).J. Biol. Chem. 264, 12977–12982.

    Google Scholar 

  • Tzeng, D. Y., Deuel, T. F., Huang, J. S., Senior, R. M., Boxer, L. A., and Baehner, R. L. (1984).Blood 64, 1123–1128.

    Google Scholar 

  • Verma, A. K., Shapes, B. G., Rice, H. M., and Boutwell, R. K. (1979).Cancer Res. 39, 419–425.

    Google Scholar 

  • Volpi, M., Molski, T. F. P., Naccache, P. H., Feinstein, M. B., and Sha'afi, R. I. (1985).Biochem. Biophys. Res. Commun. 128, 594–600.

    Google Scholar 

  • Volpp, B. D., Nauseef, W. M., and Clark, R. A. (1988).Science 242, 1295–1297.

    Google Scholar 

  • Volpp, B. D., Nauseef, W. M., Donelson, J. E., Moser, D. R., and Clark, R. A. (1989).Proc. Natl. Acad. Sci. USA 86, 7195–7199.

    Google Scholar 

  • White, J. R., Huang, C-K., Hill, J. M., Naccache, P. H., Becker, E. L., and Sha'afi, R. I. (1984).J. Biol. Chem. 259, 8605–8611.

    Google Scholar 

  • Wilson, E., Olcott, M. C., Bell, R. M., Merrill, A. H., and Lambeth, J. D. (1986).J. Biol. Chem. 261, 12616–12623.

    Google Scholar 

  • Wise, B. C., Raynor, R. L., and Kuo, J. F. (1982).J. Biol. Chem. 257, 8481–8488.

    Google Scholar 

  • Witz, G., Goldstein, B. D., Amoruso, M., Stone, D. S., and Troll, W. (1980).Biochem. Biophys. Res. Commun. 97, 883–888.

    Google Scholar 

  • Wolf, M., Sahyoun, N., Levine, H., and Cuatrecasas, P. (1984).Biochem. Biophys. Res. Commun. 122, 1268–1275.

    Google Scholar 

  • Wolf, M., Levine, H., May, W. S., Cuatrecasas, P., and Sahyoun, N. (1985a).Nature (London)317, 546–549.

    Google Scholar 

  • Wolf, M., Cuatrecasas, P., and Sahyoun, N. (1985b).J. Biol. Chem. 260, 15718–15722.

    Google Scholar 

  • Wolfson, M., McPhail, L. C., Nasrallah, V. N., and Snyderman, R. (1985).J. Immunol. 135, 2057–2062.

    Google Scholar 

  • Wright, T. C., Karnovsky, M. J., and Robinson, J. M. (1988).J. Cell Biol. 107, 57a (abstract).

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Authors and Affiliations

  1. Department of Molecular and Experimental Medicine, Research Institute of Scripps Clinic, 92037, La Jolla, California

    Paul G. Heyworth

  2. The Department of Cell Physiology, Boston Biomedical Research Institute, 02114, Boston, Massachusetts

    John A. Badwey

  3. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 02115, Boston, Massachusetts

    John A. Badwey

Authors
  1. Paul G. Heyworth
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  2. John A. Badwey
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Heyworth, P.G., Badwey, J.A. Protein phosphorylation associated with the stimulation of neutrophils. Modulation of superoxide production by protein kinase C and calcium. J Bioenerg Biomembr 22, 1–26 (1990). https://doi.org/10.1007/BF00762842

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  • DOI: https://doi.org/10.1007/BF00762842

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