Abstract
Much progress has been made in recent years toward understanding the interactions between various proteins responsible for visual transduction which are initiated by an activated state of visual pigments. However, the changes which take place in the visual pigments themselves to convert them to the activated state are more poorly understood. Many spectroscopic techniques have been applied to this problem in recent years and considerable progress has been made. A major goal of these efforts is to understand at which stages protein change occurs and to characterize its structural features. In the visual system evidence is accumulating, for example, that chromophore independent protein change begins immediately prior to lumirhodopsin formation. Considerable insight has been gained recently into the early intermediates of visual transduction and the stage is set to achieve similar understanding of the later intermediates leading to rhodopsin's activated state.
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Albeck, A., Friedman, N., Ottolenghi, M., Sheves, M., Einterz, C. M., Hug, S. J., Lewis, J. W., and Kliger, D. S. (1989).Biophys. J. 55, 233–241.
Bagley, K. A., Balogh-Nair, V., Croteau, A. A., Dollinger, G., Ebrey, T. G., Eisenstein, L., Hong, M. K., Nakanishi, K., and Vittitow, J. (1985).Biochemistry 24, 6055–6071.
Birge, R. R., Einterz, C. M., Knapp, H. M., and Murray, L. P. (1988).Biophys. J. 53, 367–385.
Buchert, J., Stefanicic, B., Doukas, A. G., Alfano, R. R., Callender, R. H., Pande, J., Akita, H., Balogh-Nair, V., and Nakanishi, K. (1983).Biophys. J. 43, 279–283.
Chabre, M., and Breton, J. (1979).Vision Res. 1, 1005–1018.
Cone, R. A. (1972).Nature New Biol. 236, 39–43.
Einterz, C. M., Hug, S. J., Lewis, J. W., and Kliger, D. S. (1990).Biochemistry 29, 1485–1491.
Eyring, G., Curry, B., Broek, A., Lugtenburg, J., and Mathies, R. (1982).Biochemistry 21, 384–393.
Ganter, U. M., Gärtner, W., and Siebert, F. (1990).Eur. J. Biochem. 18, 295–299.
Ganter, U. M., Kashima, T., Sheves, M., and Siebert, F. (1991).J. Am. Chem. Soc. 113, 4087–4092.
Henderson, R., and Schertler, G. F. X. (1990).Proc. R. Soc. London B326, 379–389.
Hofmann, K. P. (1986).Photobiochem. Photobiophys. 13, 309–327.
Horwitz, J. S., Lewis, J. W., Powers, M. A., and Kliger, D. S. (1983).Photochem. Photobiol. 37, 181–188.
Hug, S. J., Lewis, J. W., and Kliger, D. S. (1988).J. Am. Chem. Soc. 110, 1998–1999.
Hug, S. J., Lewis, J. W., Einterz, C. M., Thorgeirsson, T. E., and Kliger, D. S. (1990).Biochemistry 29, 1475–1485.
Kandori, H., Matuoka, S., Shichida, Y., and Yoshizawa, T. (1989).Photochem. Photobiol. 49, 181–184.
Lamola, A. A., Yamane, T., and Zip, A. (1974).Biochemistry 13, 738–745.
Lewis, J. W., and Kliger, D. S. (1991).Photochem. Photobiol. 54, 963–968.
Lewis, J. W., Winterle, J. S., Powers, M. A., Kliger, D. S., and Dratz, E. A. (1981).Photochem. Photobiol. 34, 375–384.
Lewis, J. W., Einterz, C. M., Hug, S. J., and Kliger, D. S. (1989).Biophys. J. 56, 1101–1111.
Lewis, J. W., Hug, S. J., Wallace-Williams, S. E., and Kliger, D. S. (1990).J. Am. Chem. Soc. 112, 6711–6712.
Lewis, J. W., van Kuijk, F. J. G. M., Thorgeirsson, T. E., and Kliger, D. S. (1991).Biochemistry 30, 11372–11376.
Liebman, P. A. (1962).Biophys. J. 2, 161–178.
Liu, R. S. H., and Asato, A. E. (1985).Proc. Natl. Acad. Sci. USA 82, 259–263.
Mathies, R., Oseroff, A. R., and Stryer, L. (1976).Proc. Natl. Acad. Sci. USA 73, 1–5.
Matthews, R. G., Hubbard, R., Brown, P. K., and Wald, G. (1963).J. Gen. Physiol. 47, 215–240.
Michel-Villaz, M., Roche, C., and Chabre, M. (1982).Biophys. J. 37, 603–616.
Monger, T. G., Alfano, R. R., and Callendar, R. H. (1979).Biophys. J. 27, 105–116.
Palings, I., Pardoen, J. A., van den Berg, E., Winkel, C., Lugtenburg, J., and Mathies, R. A. (1987).Biochemistry 26, 2544–2556.
Peters, K., Applebury, M. L., and Rentzepis, P. M. (1977).Proc. Natl. Acad. Sci. USA 74, 3119–3123.
Randall, C. E., Lewis, J. W., Hug, S. J., Björling, S. C., Eisner-Shanas, I., Friedman, N., Ottolenghi, M., Sheves, M., and Kliger, D. S. (1991).J. Am. Chem. Soc. 113, 3473–3485.
Shichida, Y., Kropf, A., and Yoshizawa, T. (1981).Biochemistry 20, 1962–1968.
Smith, S. O., Courtin, J., de Groot, H., Gebhard, R., and Lugtenburg, J. (1991).Biochemistry 30, 7409–7415.
Stewart, J. G., Baker, B. N., and Williams, T. P. (1977).Biophys. Struct. Mech. 3, 19–29.
Straume, M., Mitchell, D. C., Miller, J. L., and Litman, B. J. (1990).Biochemistry 29, 9135–9142.
Yan, M., Manor, D., Weng, G., Chao, H., Rothberg, L., Jedju, T. M., Alfano, R. R., and Callender, R. H. (1991).Proc. Natl. Acad. Sci. USA 88, 9809–9812.
Yoshizawa, T., and Shichida, Y. (1982).Methods Enzymol. 81, 634–641.
Yoshizawa, T., Shichida, Y., Matuoka, S. (1984).Vision Res. 24, 1455–1463.
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Lewis, J.W., Kliger, D.S. Photointermediates of visual pigments. J Bioenerg Biomembr 24, 201–210 (1992). https://doi.org/10.1007/BF00762678
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DOI: https://doi.org/10.1007/BF00762678