Journal of Bioenergetics and Biomembranes

, Volume 24, Issue 4, pp 351–359 | Cite as

The structure and biochemistry of the vacuolar H+ ATPase in proximal and distal urinary acidification

  • Stephen L. Gluck
Article

Abstract

Vacuolar H+ ATPases participate in renal hydrogen ion secretion in both the proximal and distal nephron. These plasma membrane forms of the vacuolar H+ ATPase are regulated physiologically to maintain the acid-base balance of the organism. Proton transporting renal cells have requirements for constitutive acidification of intracellular compartments for normal endocytic and secretory functions. Recent experiments have begun to reveal how the kidney regulates these proton pumps independently. Vacuolar H+ ATPases are a family of structurally similar enzyme which differ in the composition of specific subunits. Cytosolic regulatory enzymes are present in renal cells which may affect vacuolar H+ ATPases in certain membrane compartments selectively. The vacuolar H+ ATPase in the plasma membrane of intercalated cells resides in a specialized proton-transporting apparatus that translocates the enzyme between an intracellular membrane pool and the plasma membrane in response to physiologic stimuli.

Key words

Kidney collecting tubule intercalated cells urinary acidification acid-base balance proton pump V-ATPase regulatory proteins 

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References

  1. Alpern, R. J. (1990).Physiol. Rev. 70, 79–114.Google Scholar
  2. Arai, H., Pink, S., and Forgac, M. (1989).Biochemistry 28, 3075–3082.Google Scholar
  3. Bastani, B., Purcell, H., Hemken, P., Trigg, D., and Gluck, S. (1991).J. Clin. Invest. 88, 126–136.Google Scholar
  4. Bernasconi, P., Rausch, T., Struve, I., Morgan, L., and Taiz, L. (1990).J. Biol. Chem. 265, 17428–17431.Google Scholar
  5. Bowman, B., Oshida, W., Harris, T., and Bowman, E. J. (1989).J. Biol. Chem. 264, 15606–15612.Google Scholar
  6. Brown, D. (1989). Membrane recycling and epithelial cell function.Am. J. Physiol. 256, F1-F12.Google Scholar
  7. Brown, D., Gluck, S., and Hartwig, J. (1987).J. Cell. Biol. 105, 1637–1648.Google Scholar
  8. Brown, D., Hirsch, S., and Gluck, S. (1988a).Nature (London)331, 622–624.Google Scholar
  9. Brown, D., Hirsch, S., and Gluck, S. (1988b).J. Clin. Invest. 82, 2114–2126.Google Scholar
  10. Chin, D. J., Luskey, K., Anderson, R. G. W., Faust, J. R., Goldstein, J., and Brown, M. (1982).Proc. Natl. Acad. Sci. USA 79, 1185–1189.Google Scholar
  11. Diaz-Diaz, F. D., LaBelle, E. F., Eaton, D. C., and DuBose, T. D. (1986).Am. J. Physiol. 251, F297-F302.Google Scholar
  12. Forgac, M. (1989).Physiol. Rev. 69, 765–796.Google Scholar
  13. Gluck, S., and Caldwell, J. (1987).J. Biol. Chem. 262, 15780–15789.Google Scholar
  14. Gluck, S., and Caldwell, J. (1988).Am. J. Physiol. 254, F71-F79.Google Scholar
  15. Gurich, R. W., and DuBose, T. D. (1989).Am. J. Physiol. 257, F777-F784.Google Scholar
  16. Hays, S. R., and Alpern, R. J. (1991).J. Gen. Physiol. 98, 791–813.Google Scholar
  17. Hemken, P., Guo, X.-L., Wang, Z.-Q., Zhang, K., and Gluck, S. (1992).J. Biol. Chem. 267, 9948–9957.Google Scholar
  18. Hirsch, S., Strauss, A., Masood, K., Lee, S., Sukhatme, V., and Gluck, S. (1988).Proc. Natl. Acad. Sci. USA 85, 3004–3008.Google Scholar
  19. Madsen, K. M., and Tisher, C. C. (1985).Fed. Proc. 44, 2704–2709.Google Scholar
  20. McKinney, T. D., and Davidson, K. K. (1987).Am. J. Physiol. 253, F816-F822.Google Scholar
  21. Moriyama, Y., and Nelson, N. (1989).J. Biol. Chem. 264, 18445–18450.Google Scholar
  22. Nelson, R., Guo, X.-L., Masood, K., Kalkbrenner, M., and Gluck, S. (1992).Proc. Natl. Acad. Sci. USA 89, 3541–3545.Google Scholar
  23. Rodman, J. S., Stahl, P. D., and Gluck, S. (1991).Exp. Cell. Res. 192, 445–452.Google Scholar
  24. Sabatini, S., Kurtzman, N. A., and Yang, B.-L. (1990a).Kidn. Int. 37, 79–84.Google Scholar
  25. Sabatini, S., Laski, M. E., and Kurtzman, N. A. (1990b).Am. J. Physiol. 258, F297-F304.Google Scholar
  26. Sabolic, I., Haase, W., and Burckhardt, G. (1985).Am. J. Physiol. 248, F835-F844.Google Scholar
  27. Satlin, L. M., and Schwartz, G. J. (1989).J. Cell Biol. 109, 1279–1288.Google Scholar
  28. Schwartz, G. J., Barasch, J., and Al-Awqati, Q. (1985).Nature (London)318, 368–371.Google Scholar
  29. Schwartz, G. J., Satlin, L. M., and Bergmann, J. E. (1988).Am. J. Physiol. 255, F1003-F1014.Google Scholar
  30. Simon, B. J., and Burckhardt, G. (1990).J. Membr. Biol. 117, 141–151.Google Scholar
  31. Steinmetz, P. R. (1986).Am. J. Physiol. 251, F173–87.Google Scholar
  32. Stetson, D. L., and Steinmetz, P. R. (1986).Pflugers Arch. 407(Suppl. 2), S80-S84.Google Scholar
  33. Südhof, T. C., Fried, V. A., Stone, D. K., Johnston, P. A., and Xie, X.-S. (1989).Proc. Natl. Acad. Sci. USA 86, 6067–6071.Google Scholar
  34. Turrini, F., Sabolic, I., Zimolo, Z., Moewes, B., and Burckhardt, G. (1989).J. Membr. Biol. 107, 1–12.Google Scholar
  35. Van Adelsberg, J., and Al-Awqati, Q. (1986).J. Cell. Biol. 102, 1638–1645.Google Scholar
  36. Verlander, J. W., Madsen, K. M., and Tisher, C. C. (1987).Am. J. Physiol. 253, F1142-F1156.Google Scholar
  37. Verlander, J. W., Madsen, K. M., Larsson, L., Cannon, J. K., and Tisher, C. C. (1989).Am. J. Physiol. 256, F454-F462.Google Scholar
  38. Wang, Z.-Q., and Gluck, S. (1990).J. Biol. Chem. 265, 21957–21965.Google Scholar
  39. Wang, Z. Q., and Gluck, S. “Properties of the lysosomal H+ ATPase from bovine kidney,” manuscript in preparation.Google Scholar
  40. Yurko, M., and Gluck, S. (1987).J. Biol. Chem. 262, 15770–15779.Google Scholar
  41. Zhang, K., Wang, Z.-Q., and Gluck, S. (1992a). “A cytosolic inhibitor of vacuolar H+ ATPases from mammalian kidney,”J. Biol. Chem., in press.Google Scholar
  42. Zhang, K., Wang, Z.-Q., and Gluck, S. (1992b).J. Biol. Chem. 267, 9701–9705.Google Scholar

Copyright information

© Plenum Publishing Corporation 1992

Authors and Affiliations

  • Stephen L. Gluck
    • 1
    • 2
  1. 1.Departments of Medicine and Cell Biology and PhysiologyWashington University School of MedicineUSA
  2. 2.the Renal Division, Department of MedicineJewish Hospital of St. LouisSt. Louis

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