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Semi-synthetic digoxigenin glycosides

  • Chemistry
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Pharmaceutical Chemistry Journal Aims and scope

Conclusions

Starting with digoxigenin, L-rhamnose, D-glucose, and D-xylose, the monoglycosides digoxigenin-3-α-L-rhamnopyranoside, 3-β-D-glycopyranoside, and 3-β-D-xylopyranoside have been synthesized in approximately 40% yield. The biosides digoxigenin 3,12-di-β-D-glucopyranoside and 3,12-di-β-D-xylopyranoside were also obtained in approximately 3% yield. The glycosides obtained possessed high cardiotonic activity.

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Authors and Affiliations

  1. Kharkov Pharmaceutical Chemistry Scientific-Research Institute, USSR

    I. F. Makarevich

Authors
  1. I. F. Makarevich
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Translated from Khimiko-Farmatsevticheskii Zhurnal, No. 5, pp. 23–27, May, 1969.

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Makarevich, I.F. Semi-synthetic digoxigenin glycosides. Pharm Chem J 3, 266–269 (1969). https://doi.org/10.1007/BF00762427

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  • DOI: https://doi.org/10.1007/BF00762427

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