Journal of Bioenergetics and Biomembranes

, Volume 24, Issue 5, pp 469–477 | Cite as

Functional sites in F1-ATPases: Location and interactions

  • William S. Allison
  • Jean-Michel Jault
  • Shaoqiu Zhuo
  • Seung R. Paik
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Abstract

This review focuses on the location and interaction of three functional sites in F1-ATPases. These are catalytic sites which are located in β subunits, noncatalytic nucleotide-binding sites which are located at interfaces of α and β subunits and modulate the hydrolytic activity of the enzyme, and a site that binds inhibitory amphipathic cations which is at an interface of α and β subunits. The latter site may participate in transmission of conformational signals between catalytic sites in F1 and the proton-conducting apparatus of F0 in the intact ATP synthases.

Key words

Catalytic sites regulatory sites inhibitory amphipathic cations signal transmission 

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Copyright information

© Plenum Publishing Corporation 1992

Authors and Affiliations

  • William S. Allison
    • 1
  • Jean-Michel Jault
    • 1
  • Shaoqiu Zhuo
    • 1
  • Seung R. Paik
    • 1
  1. 1.Department of ChemistryUniversity of California at San DiegoLa Jolla

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