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Cytochromec oxidase metal centers: Location and function

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Abstract

Cytochromec oxidase ofParacoccus denitrificans is spectroscopically and functionally very similar to the mammalian enzyme. However, it has a very much simpler quaternary structure, consisting of only three subunits instead of the 13 of the bovine enzyme. The known primary structure of theParacoccus denitrificans subunits, the knowledge of a large number of sequences from other species, and data on the controlled proteolytic digestion of the enzyme allow structural restrictions to be placed on the models describing the binding of the active metal centers to the polypeptide structure.

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  1. Michele Müller

    Present address: Medizinische Klinik, Inselspital, CH-3010, Bern, Switzerland

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  1. Institut für Biochemie und Molekularbiologie der Universität Bern, Bühlstrasse 28, CH-3012, Bern, Switzerland

    Michele Müller & Angelo Azzi

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Müller, M., Azzi, A. Cytochromec oxidase metal centers: Location and function. J Bioenerg Biomembr 23, 291–302 (1991). https://doi.org/10.1007/BF00762223

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