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Molecular genetics of F1-ATPase fromEscherichia coli

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Abstract

We have reviewed recent molecular biological studies on F1-ATPase ofEscherichia coli and emphasized the advantages of using the bacterium in studies on this important enzyme. All subunits had homologies of varied degrees with those from other organisms. Mutations of F1 subunits caused defects in catalysis and assembly. Defects of the mutant enzymes were studied extensively together with the determination of the amino acid substitutions. Extensive molecular biological studies may help greatly in understanding the normal mechanism and assembly of the complex.

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Authors and Affiliations

  1. Department of Organic Chemistry and Biochemistry, The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, 567, Ibaraki, Osaka, Japan

    Masamitsu Futai, Takato Noumi & Masatomo Maeda

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  1. Masamitsu Futai
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  2. Takato Noumi
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Futai, M., Noumi, T. & Maeda, M. Molecular genetics of F1-ATPase fromEscherichia coli . J Bioenerg Biomembr 20, 41–58 (1988). https://doi.org/10.1007/BF00762137

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