Abstract
The formation of 2,2,4-trisubstituted 2,3-dihydro-1H-1,5-benzodiazepines in the reactions of acetylarenes with 4-ethoxy- and 3,5-dimethyl-1,2-phenylenediamine was studied. The effect of the substituents on the individual stages of the reactions is discussed. A quantum-chemical calculation of the relative nucleophilicity of 1,2-phenylenediamine, 2,3-diaminopyridine, and 3,4-diaminofurazan was undertaken.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 370–375, March, 1987.
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Orlov, V.D., Desenko, S.M. & Kiroga, K. Aromatic derivatives of 2,3-dihydro-1H-1,5-benzodiazepine. Chem Heterocycl Compd 23, 311–315 (1987). https://doi.org/10.1007/BF00761991
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DOI: https://doi.org/10.1007/BF00761991