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Stability of penicillins in aqueous solutions I. Oxacillin and phenoxymethylpenicillin

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Conclusions

Experimental data were obtained on the stability of phenoxymethylpenicillin and oxacillin in aqueous solutions with various pH values and at various temperatures. The antibiotics possess their maximum stability in the region of pH 6.0–7.0.

Nomograms were compiled, permitting a determination of the percent inactivation of penicillins at any pH value and temperature within the indicated limits.

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Authors and Affiliations

  1. All-Union Scientific Research Institute of Antibiotics, Moscow

    A. P. Kondrat'eva & V. P. Bruns

Authors
  1. A. P. Kondrat'eva
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  2. V. P. Bruns
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Translated from Khimiko-Farmatsevticheskii Zhurnal, No. 12, pp. 30–37, December, 1967.

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Kondrat'eva, A.P., Bruns, V.P. Stability of penicillins in aqueous solutions I. Oxacillin and phenoxymethylpenicillin. Pharm Chem J 1, 696–701 (1967). https://doi.org/10.1007/BF00761593

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  • DOI: https://doi.org/10.1007/BF00761593

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