Pharmaceutical Chemistry Journal

, Volume 1, Issue 12, pp 696–701 | Cite as

Stability of penicillins in aqueous solutions I. Oxacillin and phenoxymethylpenicillin

  • A. P. Kondrat'eva
  • V. P. Bruns
In Honor of the Jubilee of the Great October Socialist Revolution

Conclusions

Experimental data were obtained on the stability of phenoxymethylpenicillin and oxacillin in aqueous solutions with various pH values and at various temperatures. The antibiotics possess their maximum stability in the region of pH 6.0–7.0.

Nomograms were compiled, permitting a determination of the percent inactivation of penicillins at any pH value and temperature within the indicated limits.

Keywords

Experimental Data Aqueous Solution Organic Chemistry Penicillin Oxacillin 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature cited

  1. 1.
    E. Brandl and H. Margreiter, Öt. Chem.-Ztg.,55, No. 5, 11 (1954).Google Scholar
  2. 2.
    A. P. Kondrat'eva and B. P. Bruns, Med. Prom. SSSR, No. 12, 30 (1957).Google Scholar
  3. 3.
    W. M. M. Kirby, L. S. Rosenfeld, et al., J. A. M. A.,180, 318 (1962).Google Scholar
  4. 4.
    J. T. Smith, J. M. T. Hamilton-Miller, and R. Knox, Nature,195, 1300 (1962).Google Scholar
  5. 5.
    W. M. M. Kirby, J. D. Allen, L. S. Rosenfeld, et al., In: Antimicrobial Agents and Chemotherapy, New York (1962), p. 757.Google Scholar
  6. 6.
    M. Barber and P. M. Waterworth, Brit. Med. J.,1, 1159 (1962).Google Scholar
  7. 7.
    I. I. Inozemtseva et al., Antibiotiki, No. 7, 497 (1966).Google Scholar
  8. 8.
    A. V. Gorodetskaya and T. E. Rostkovskaya, Med. Prom. SSSR, No. 4, 32 (1951).Google Scholar
  9. 9.
    British Pharmacopoeia, London (1963).Google Scholar
  10. 10.
    E. Mislovitser, Determination of the Hydrogen Ion Concentration in Liquids [in Russian], Leningrad (1932), p. 331.Google Scholar
  11. 11.
    R. Brodersen, Trans. Faraday Soc.,43, 351 (1947).Google Scholar
  12. 12.
    Idem, Acta Chem. Scand.,1, 403 (1947).Google Scholar
  13. 13.
    Idem, Acta Pharmacol. (Kbh.),3, 345 (1947).Google Scholar
  14. 14.
    H. D. Rapson et al., J. Pharm. (London),40, 222 (1963).Google Scholar
  15. 15.
    A. P. Kondrat'eva and B. P. Bruns, Antibiotiki, No. 6, 511 (1962).Google Scholar

Copyright information

© Consultants Bureau 1968

Authors and Affiliations

  • A. P. Kondrat'eva
    • 1
  • V. P. Bruns
    • 1
  1. 1.All-Union Scientific Research Institute of AntibioticsMoscow

Personalised recommendations