Pharmaceutical Chemistry Journal

, Volume 1, Issue 12, pp 696–701 | Cite as

Stability of penicillins in aqueous solutions I. Oxacillin and phenoxymethylpenicillin

  • A. P. Kondrat'eva
  • V. P. Bruns
In Honor of the Jubilee of the Great October Socialist Revolution


Experimental data were obtained on the stability of phenoxymethylpenicillin and oxacillin in aqueous solutions with various pH values and at various temperatures. The antibiotics possess their maximum stability in the region of pH 6.0–7.0.

Nomograms were compiled, permitting a determination of the percent inactivation of penicillins at any pH value and temperature within the indicated limits.


Experimental Data Aqueous Solution Organic Chemistry Penicillin Oxacillin 
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Copyright information

© Consultants Bureau 1968

Authors and Affiliations

  • A. P. Kondrat'eva
    • 1
  • V. P. Bruns
    • 1
  1. 1.All-Union Scientific Research Institute of AntibioticsMoscow

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