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Synthesis of several 4-aryl derivatives of 1,2-dithiole-3-thione and 1, 2-ditholium and their choleretic activity

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Conclusions

  1. 1.

    A series of 4-aryl-1, 2-dithiole-3-thiones and 4-aryl-1, 2-dithiolium salts, as well as two 5-aryl-1,2-dithiole-3-thiones, have been synthesized, and their choleretic activities have been investigated.

  2. 2.

    The 5-aryl-1,2-dithiole-3-thione is more active in its choleretic effect than is the 4-isomer. The 4-aryl-1,2-dithiolium derivatives are more effective than the corresponding 4-aryl-1,2-dithiole-3-thiones. The choleretic activity of the 5-(p-methoxyphenyl)-1, 2-dithiole-3-thione that was synthesized did not seem to be as high as has been claimed in the literature.

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Literature cited

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Authors and Affiliations

  1. Tomsk Medicinal Institute, USSR

    M. G. Voronkov, T. V. Lanina, A. S. Saratikov, M. I. Solov'eva & L. I. Dubro

  2. Institute for Organic Synthesis of the Academy of Sciences of the Lithuanian SSR, Riga

    M. G. Voronkov, T. V. Lanina, A. S. Saratikov, M. I. Solov'eva & L. I. Dubro

Authors
  1. M. G. Voronkov
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  2. T. V. Lanina
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  3. A. S. Saratikov
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  4. M. I. Solov'eva
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  5. L. I. Dubro
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, No. 11, pp. 18–23, November, 1967.

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Voronkov, M.G., Lanina, T.V., Saratikov, A.S. et al. Synthesis of several 4-aryl derivatives of 1,2-dithiole-3-thione and 1, 2-ditholium and their choleretic activity. Pharm Chem J 1, 621–625 (1967). https://doi.org/10.1007/BF00760820

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  • DOI: https://doi.org/10.1007/BF00760820

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