Conclusions
-
1.
Film-forming agents based on stearic acid monoglyceride and cetyl alcohol are the least permeable to water vapor and are fairly permeable to gastric intestinal juices.
-
2.
The use of shellac as a film-forming agent is undesirable, since films of this material, which have a lower moisture-permeability than other films, can considerably impair the absorption of the medicinal substance.
-
3.
Ethylcellulose is the most permeable to water vapor and is only slightly permeable to artificial gastric and intestinal juices.
-
4.
A method of evaluating the permeability of films to water vapor in combination with a test of the degree of permeability of the films to gastric and intestinal juices that has been described permits a rapid and fairly accurate (error not greater than 5%) evaluation of the protective properties of various filmforming agents, the influences of the individual components of the lacquer on the properties of the film, and the suitability of the lacquer for pharmaceutical coatings.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature cited
A. G. Daragan, in: Modern Methods of Producing Shaped Drugs and Galenical Preparations [in Russian], Moscow (1962), p. 69.
A. Ya. Drinberg, The Technology of Film-forming Substances [in Russian], Leningrad (1955).
British Pharmacopoeia, London (1963), pp. 305, 1157.
K. Münzel, Pharm. Acta Helv., No. 2, 38 (1963).
V. Coletta and H. Rubin, J. Pharm. Sci.,53, 953 (1964).
Yu. K. Sander, in: Proceedings of the 2nd All-Union Conference of Pharmacists [in Russian], Moscow (1961), p. 154.
A. G. Daragan, Aptechn. Delo, No. 5, 25 (1964).
D. W. Doerr, E. R. Series, and D. Deardorff, J. Pharm. Sci.,43, 433 (1954).
E. P. Winters and D. Deardorff, J. Pharm. Sci.,53, 639 (1964).
L. Lachman and A. Drubulus, J. Pharm. Sci.,53, 639 (1964).
T. Higuchi and A. Aguiar, J. Pharm. Sci.,48, 574 (1959).
M. Patel, J. M. Patel, and A. P. Lemberger, J. Pharm. Sci.,53, 286 (1964).
R. J. Nessel, H. G. DeKay, and G. S. Banker, J. Pharm. Sci.,53, 882 (1964).
I. Utsumi, T. Ida, and S. Takahashi, J. Pharm. Sci.,50, 592 (1961).
B. J. Münden, H. G. DeKay, and G. S. Banker, J. Pharm. Sci.,53, 395 (1964).
J. L. Kanig and H. Goodman, J. Pharm. Sci.,51, 77 (1962).
S. V. Yakubovich, A Review of the Literature on the Paint and Varnish Industry [in Russian], Moscow, No. 12 (1948).
S. V. Yakubovich, The Testing of Paint and Varnish Materials and Coatings [in Russian], Moscow (1952).
German Federal Republic Patent No. 1056,786 (1960).
Pharmacopoeia of the United States, XVI, New York (1960).
Yu. B. Borisenko, R. M. Safiulin, and S. A. Nosovits'ka, Farmatsevtichn. Zh., No. 3, 36 (1966).
British Patent No. 899,900.
Handbook of Chemistry [in Russian], Moscow (1962).
Paint and Varnish Materials, Raw Materials and Intermediates. Handbook [in Russian], Moscow (1961).
Yu. B. Borisenko, R. M. Safiulin, and S. A. Nosovits'ka, Farmatsevtichn. Zh., No. 5, 32 (1966).
Author information
Authors and Affiliations
Additional information
Translated from Khimiko-Farmatsevticheskii Zhurnal, No. 10, pp. 54–58, October, 1968.
Rights and permissions
About this article
Cite this article
Ageeva, M.G., Lazareva, E.N. The selection of moisture-resistant coatings for tablets and granules. Pharm Chem J 2, 582–585 (1968). https://doi.org/10.1007/BF00759644
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00759644