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2-β-(N-arylpiperazino) ethyl indandiones-1,3 and indandiols-1,3

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Conclusion

By the action of N-arylpiperazines on the tosylates of 2-β-hydroxyethyl-2-phenyl and 2-methylsubstituted indandiones-1,3 one obtains 2-β-(N-arylpiperazino) ethyl derivatives of 2-substituted indandiones-1,3 which are reduced by sodium borane to the corresponding indandiol-1,3 derivatives. The arylpiperazino derivatives of 2-substituted indandiones-1,3 and indandiols-1,3 have neurotropic properties. A certain association between structure, toxicity, and pharmacological action of these compounds was noted.

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Literature cited

  1. A. K. Aren, Ya. Ya. Ozol, I. A. Abolinya, et al., Khim.- Farmats. Zh., No. 6, 9 (1967).

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Authors and Affiliations

  1. Institute of Organic Synthesis, Academy of Sciences of the Latvian SSR, Riga

    I. A. Berzinya, S. K. Germane, Ya. Ya. Dregeris & A. K. Aren

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  1. I. A. Berzinya
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  2. S. K. Germane
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  3. Ya. Ya. Dregeris
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  4. A. K. Aren
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, No. 10, pp. 25–29, October, 1968.

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Berzinya, I.A., Germane, S.K., Dregeris, Y.Y. et al. 2-β-(N-arylpiperazino) ethyl indandiones-1,3 and indandiols-1,3. Pharm Chem J 2, 553–556 (1968). https://doi.org/10.1007/BF00759632

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  • DOI: https://doi.org/10.1007/BF00759632

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