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Comparative study of various compounds used as diluents in tableting

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Pharmaceutical Chemistry Journal Aims and scope

Conclusions

  1. 1.

    Calcium hydrophosphate, calcium sulfate, basic magnesium carbonate, beet sugar, and glucose are compared as diluents in tableting toxic and strongly aggressive medicinal preparations.

  2. 2.

    It is shown that tableted preparations based on calcium hydrophosphate, calcium sulfate and basic magnesium carbonate are superior in quality and have more effect on the compacting conditions than those based on beet sugar and glucose.

  3. 3.

    It is shown that calcium hydrophosphate, calcium sulfate, and basic magnesium carbonate can be used as diluents in tableting promedol, codeine, ethylmorphine hydrochloride, diabazol, phenobarbital, papaverine hydrochloride, caffeine-sodium benzoate, and also mixtures containing phenobarbital and papaverine hydrochloride.

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Authors and Affiliations

  1. I. M. Sechenov Institute of Medicine, Moscow

    V. G. Gandel'

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  1. V. G. Gandel'
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Translated from Khimiko Farmatsevticheskii Zhurnal, No. 2, pp. 51–56, February, 1969.

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Gandel', V.G. Comparative study of various compounds used as diluents in tableting. Pharm Chem J 3, 109–113 (1969). https://doi.org/10.1007/BF00759341

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  • DOI: https://doi.org/10.1007/BF00759341

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