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Synthesis of 6-mercaptopurine and 6-[(1-methyl-4-nitroimidazol-5-yl)mercapto]purine tagged at the sulfur

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Literature cited

  1. G. H. Hittching and G. H. van der Werff, “Antagonists of nucleic acid VI. Purines,” J. Biol. Chem.,192, 505–510 (1951).

    Google Scholar 

  2. O. Yu. Magidson and V. I. Sokolova, “Synthesis of 6-mercaptopurine,” in: Collection of the proceedings of the All-Union Scientific-Research Institute of Pharmaceutical Chemistry [Principal Directions of the Projects [in Russian], No. 1 (1959), pp. 243–248.

    Google Scholar 

  3. C. B. Elion and G. H. Hitchings, “The synthesis of 8-14 C-6-mercaptopurine and 6-35 Smercaptopurine,” J. Am. Chem. Soc.,76, 4027–4028 (1954).

    Google Scholar 

  4. J. Morávek and Z. Nejedly,: Labelling of 6-mercaptopurine and 6-mercaptopurine riboside by an exchange reaction with elementary sulphur35S,” Chem. a Industr. (Lond.), 30–32 (1960).

  5. G. H. Hitchings and G. B. Elion, “Activity of heterocyclic derivatives of 6-mercaptopurine and 6-thioguanine in adenocarcinoma-755, Proc. Am. Ass. Cancer Res.,3, No. 1, 27–28 (1959).

    Google Scholar 

  6. G. H. Hittchings and G. B. Elion, US Patent No. 3056785 (1962); Chem. Abstr.,58, 57d (1963).

  7. P. M. Kochergin and I. S. Shmidt, “Synthesis of azathioprine,” Med. Prom. SSSR, No. 8, 6–8 (1965).

    Google Scholar 

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Translated from Khimiko-Farmatsevticheskii Zhurnal. Vol. 9, No. 9, pp. 24–26, September, 1975.

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Singin, A.S., Safonova, T.S. Synthesis of 6-mercaptopurine and 6-[(1-methyl-4-nitroimidazol-5-yl)mercapto]purine tagged at the sulfur. Pharm Chem J 9, 572–574 (1975). https://doi.org/10.1007/BF00758852

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  • DOI: https://doi.org/10.1007/BF00758852

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