Skip to main content
Log in

Role of 0(6)-alkylguanine DNA alkyltransferase in the implementation of the antitumor activity of N-nitrosoureas (a review)

  • Molecular Biological Problems of the Creation of Drugs and Study of the Mechanism of their Action
  • Published:
Pharmaceutical Chemistry Journal Aims and scope

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Literature cited

  1. L. B. Gorbacheva, G. V. Kukushkina, Khim-farm. Zh., No. 4, 25–34 (1979).

    Google Scholar 

  2. L. B. Gorbacheva and G. V. Kukushkina, Éksp. Onkol.,3, No. 6, 21–28 (1981).

    Google Scholar 

  3. L. B. Gorbacheva and G. V. Kukushkina, Khim.-farm. Zh., No. 4, 390–398 (1987).

    Google Scholar 

  4. A. Ya. Likhachev, Vopr. Onkol., No. 1, 3–11 (1987).

    Google Scholar 

  5. N. M. Emanuel', D. B. Korman, L. A. Ostrovskii, et al., Nitrosoalkylureas — a New Class of Antitumor Drugs [in Russian], Moscow (1978).

  6. N. P. Pal'mina, V. D. Gaintseva, and N. P. Sezina, Vopr. Onkol., No. l, 80–83 (1980).

    Google Scholar 

  7. I. S. Sokolova, G. V. Kukushkina, and L. B. Gorbacheva, Dokl. Akad. Nauk SSSR,245, No. 1, 260–264 (1979).

    Google Scholar 

  8. T. Aida, W. J. Bodell, Cancer Res.,47, 1361–1366 (1987).

    Google Scholar 

  9. J. A. Alexander, B. J. Bowdon, and G. P. Wheeler, ibid.,46, 6024–6028 (1986).

    Google Scholar 

  10. M. A. Babich and R. S. Day, III, Mutat. Res.,184, 245–254 (1987).

    Google Scholar 

  11. L. R. Barrows, A. H. Borchers, and M. Paxton, Carcinogenesis,8, 1853–1859 (1987).

    Google Scholar 

  12. N. A. Berger, S. J. Berger, and S. L. Gerson, Anti-Cancer Drug Design,2, 203–209 (1987).

    Google Scholar 

  13. W. J. Bodell, T. Aida, M. S. Berger, et al., Carcinogenesis,7, 879–883 (1986).

    Google Scholar 

  14. J. Brennand and G. P. Margison, ibid., pp. 185–188.

    Google Scholar 

  15. J. Brennand and G. P. Margison, Proc. Natl. Acad. Sci. USA,83, 6292–6296 (1986).

    Google Scholar 

  16. T. P. Brent, Cancer Res.,46, 2320–2323 (1986).

    Google Scholar 

  17. T. P. Brent, P. J. Houghton, and J. A. Houghton, Proc. Natl. Acad. Sci. USA,82, 2985–2989 (1985).

    Google Scholar 

  18. T. P. Brent, S. O. Lestrud, D. G. Smith, et al., Cancer Res.,47, 3384–3387 (1987).

    Google Scholar 

  19. T. P. Brent, J. S. Remack, and D. G. Smith, ibid., pp. 6185–6188.

    Google Scholar 

  20. C. V. Catapano, M. Broggini, E. E. Erbo, et al., ibid., pp. 4884–4889.

    Google Scholar 

  21. A. Cohen and C. Leung, Carcinogenesis,7, 1877–1879 (1986).

    Google Scholar 

  22. S. M. D'Ambrosio, M. J. Samuel, T. A. Dutta-Choudhury, et al., Cancer Res.,47, 51–55 (1987).

    Google Scholar 

  23. R. S. Day, III, C. H. J. Ziolkowski, D. A. Scudiero, et al., Nature,288, 724–727 (1980).

    Google Scholar 

  24. S. W. Dean, N. W. Gibson, and K. D. Tew, Molec. Pharmacol.,30, 77–80 (1986).

    Google Scholar 

  25. W. Dempke, P. Nehls, U. Wandl, et al., J. Cancer Res. Clin. Oncol.,113, 387–391 (1987).

    Google Scholar 

  26. B. Demple, B. Sedgwick, P. Robins, et al., Proc. Natl. Acad. Sci. USA,82, 2688–2692 (1985).

    Google Scholar 

  27. M. E. Dolan, C. D. Corsico, and A. E. Pegg, Biochim. Biophys. Res. Commun.,123, 178–185 (1985).

    Google Scholar 

  28. M. E. Dolan, K. Morimoto, and A. E. Pegg, Cancer-Res.,45, 6413–6417 (1985).

    Google Scholar 

  29. M. E. Dolan and A. E. Pegg, Carcinogenesis,6, 1611–1614 (1985).

    Google Scholar 

  30. M. E. Dolan, G. S. Young, and A. E. Pegg, Cancer Res.,46, 4500–4504 (1986).

    Google Scholar 

  31. J. Domoradzki, A. E. Pegg, M. E. Dolan, et al., Carcinogenesis,5, 1641–1647 (1984).

    Google Scholar 

  32. J. Domoradzki, A. E. Pegg, M. E. Dolan, et al., ibid.,6, 1823–1826 (1985).

    Google Scholar 

  33. L. C. Erickson, G. Laurent, N. A. Sharley, et al., Nature,288, 727–729 (1980).

    Google Scholar 

  34. G. Frosina and F. Laval, Carcinogenesis,8, 91–95 (1987).

    Google Scholar 

  35. S. L. Gerson, K. Miller, and N. A. Berger. J. Clin. Invest.,76, 2106–2114 (1985).

    Google Scholar 

  36. S. L. Gerson, J. E. Trey, K. Miller, et al., Cancer Res.,7, 745–749 (1986).

    Google Scholar 

  37. S. L. Gerson, J. E. Trey, K. Miller, et al., Cancer Res.,47, 89–95 (1987).

    Google Scholar 

  38. N. W. Gibson, C. Zlotogorski, and L. C. Erickson, Carcinogenesis,6, 445–450 (1985).

    Google Scholar 

  39. N. W. Gibson, J. A. Hartley, D. Barnes, et al., Cancer Res.,46, 4995–4998 (1986).

    Google Scholar 

  40. N. W. Gibson, J. Hartley, and R. J. La France, Carcinogenesis,7, 259–265 (1986).

    Google Scholar 

  41. N. W. Gibson, J. A. Hartley, R. J. La France, et al., Cancer Res.,46, 4999–5003 (1986).

    Google Scholar 

  42. R. Goth and M. F. Rajewsky, Proc. Natl. Acad. Sci. USA,71, 639–643 (1974).

    Google Scholar 

  43. R. Goth-Goldstein, Cancer Res.,40, 2623–2624 (1980).

    Google Scholar 

  44. J. A. Hartley and N. W. Gibson, ibid.,46, 3871–3875 (1986).

    Google Scholar 

  45. K. Hemminki and D. B. Ludlum, J. Natl. Cancer Inst.,73, 1021–1028 (1984).

    Google Scholar 

  46. N. Huh and M. F. Rajewsky, Carcinogenesis,7, 435–439 (1986).

    Google Scholar 

  47. K. Ishizaki, T. Tsijimura, H. Yawata, et al., Mutat. Res.,166, 135–141 (1986).

    Google Scholar 

  48. P. Karran and T. Lindahl, Nature,280, 76–77 (1979).

    Google Scholar 

  49. H. Kataoka, J. Hall, and P. Karran, EMBO J.,5, 3195–3200 (1986).

    Google Scholar 

  50. T. Kokunai, N. Tamaki, and S. Matsumoto, J. Natl. Cancer Inst.,79, 119–122 (1987).

    Google Scholar 

  51. F. Laval and J. Lavai, Proc. Natl. Acad. Sci. USA,81, 1062–1066 (1984).

    Google Scholar 

  52. T. Lindahl, Br. J. Cancer,56, 91–95 (1987).

    Google Scholar 

  53. D. B. Ludlum, J. R. Mehta, and W. P. Tong, Cancer Res.,46, 3353–3357 (1987).

    Google Scholar 

  54. T. V. McCarthy, P. Karran, and T. Lindahl, EMBO J.,3, 545–550 (1984).

    Google Scholar 

  55. T. V. McCarthy and T. Lindahl, Nucl. Acids Res.,13, 2683–2698 (1985).

    Google Scholar 

  56. H. Mitani, K. Ito, M. Fujino, and H. Takebe, Mutat. Res.,191, 201–205 (1987).

    Google Scholar 

  57. B. Myrnes, K. E. Giercksky, and H. Krokan, Carcinogenesis,4, 1565–1568 (1983).

    Google Scholar 

  58. Y. Nakabeppu, H. Kondo, S. I. Kawabata, et al., J. Biol. Chem.,260, 7281–7288 (1985).

    Google Scholar 

  59. A. W. Prestayko et al., Eds., Nitrosoureas: Current Status and New Developments, New York (1981).

  60. B. Serrou et al., Eds., Nitrosoureas in Cancer Treatment, Amsterdam (1981).

  61. M. Olsson, T. Lidhal, J. Biol. Chem.,255, 10569–10571 (1980).

    Google Scholar 

  62. A. E. Pegg, M. Roberfroid, C. Von Bahr, et al., Proc. Natl. Acad. Sci. USA,79, 5162–5165 (1982).

    Google Scholar 

  63. A. E. Pegg, L. Wiest, R. S. Foote, et al., J. Biol. Chem.,258, 2327–2333 (1983).

    Google Scholar 

  64. L. Samson, B. Derfler, and E. A. Waldstein, Proc. Natl. Acad. Sci. USA,83, 5607–5610 (1986).

    Google Scholar 

  65. L. Samson and S. Linn, Carcinogenesis,8, 227–230 (1987).

    Google Scholar 

  66. E. Sariban, K. W. Kohn, C. Zlotogorski, et al., Cancer Res.,47, 3988–3994 (1987).

    Google Scholar 

  67. M. S. Satoh, N. Huh. J. Horie, et al., J. Jpn. Cancer Res. (Gann),78, 1094–1099 (1987).

    Google Scholar 

  68. D. A. Scicchitano and A. E. Pegg, Mutat. Res.,192, 207–210 (1987).

    Google Scholar 

  69. D. A. Scudiero, S. A. Meyer, B. E. Clatterbuck, et al., Cancer Res.,44, 2467–2474 (1984).

    Google Scholar 

  70. B. Sedgwick, Molec. Gen. Genet.,191, 466–472 (1983).

    Google Scholar 

  71. B. Singer, D. Grunberger, Molecular Biology of Mutagens and Carcinogens, New York (1983).

  72. R. Sklar and B. Strauss, Nature,289, 417–420 (1981).

    Google Scholar 

  73. M. Tisdale, Biochem. Pharmacol.,36, 457–462 (1987).

    Google Scholar 

  74. W. P. Tong and D. B. Ludlum, Cancer Res.,41, 380–382 (1981).

    Google Scholar 

  75. W. P. Tong, M. C. Kirk, and D. B. Ludlum, ibid.,42, 3102–3105 (1982).

    Google Scholar 

  76. J. K. Wiencke and W. J. Bodell, ibid.,45, 4798–4808 (1985).

    Google Scholar 

  77. R. S. Wu, S. Hurst-Calderone, and K. W. Kohn, ibid.,47, 6229–6235 (1987).

    Google Scholar 

  78. T. Yagi, D. B. Yarosh, and R. S. Day, III, Carcinogenesis,5, 593–600 (1984).

    Google Scholar 

  79. T. Yagi and R. S. Day, III, Mutat. Res.,184, 223–227 (1987).

    Google Scholar 

  80. D. B. Yarosh, R. C. Foote, S. Mitra, et al., Carcinogenesis,4, 199–205 (1983).

    Google Scholar 

  81. D. B. Yarosh, M. Rice, and R. S. Day, III, Mutat. Res.,131, 27–36 (1984).

    Google Scholar 

  82. D. B. Yarosh, ibid.,145, 1–16 (1985).

    Google Scholar 

  83. D. B. Yarosh, A. J. Fornance, and R. S. Day, III, Carcinogenesis,6, 949–953 (1985).

    Google Scholar 

  84. D. B. Yarosh, S. Hurst-Calderone, M. A. Babich, et al., Cancer Res.,46, 1663–1668 (1986).

    Google Scholar 

  85. D. B. Yarosh, D. Barnes, and L. C. Erickson, Carcinogenesis,7, 1603–1606 (1986).

    Google Scholar 

  86. W. J. Zeller, M. R. Berger, T. Henne, et al., Cancer Res.,46, 1714–1716 (1986).

    Google Scholar 

  87. C. Zlotogorski, L. C. Erickson, Carcinogenesis,5, 83–87 (1984).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

Translated from Khimiko-farmatsevticheskii Zhurnal, Vol. 23, No. 4, pp. 389–396, April, 1989.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gorbacheva, L.B., Kukushkina, G.V. Role of 0(6)-alkylguanine DNA alkyltransferase in the implementation of the antitumor activity of N-nitrosoureas (a review). Pharm Chem J 23, 281–287 (1989). https://doi.org/10.1007/BF00758413

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00758413

Keywords

Navigation